Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 1/20 | 0.48 |
| ▸ | BCAT2 | O15382 | 2/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 4/20 | 0.41 |
| ▸ | IKBKB | O14920 | 2/20 | 0.41 |
| ▸ | F2 | P00734 | 2/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.41 |
| ▸ | CHUK | O15111 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17593030 | 0.85 | BCAT2 (0.49) | EDNRABCAT2KEAP1NFE2L2PARP1 | |
| SCHEMBL364343 | 0.81 | BCAT2 (0.56) | BCAT2KEAP1NFE2L2F2PRSS1 | |
| SCHEMBL27214460 | 0.80 | BCAT2 (0.63) | BCAT2KEAP1NFE2L2PARP1IKBKB | |
| SCHEMBL15562588 | 0.80 | EDNRA (0.51) | EDNRABCAT2KEAP1NFE2L2CA1 | |
| Hydrochloric Acid SCHEMBL27374126 | 0.79 | BCAT2 (0.54) | BCAT2KEAP1NFE2L2F2PRSS1 | |
| SCHEMBL530286 | 0.78 | FABP4 (0.57) | BCAT2KEAP1NFE2L2BRD4PARP1 | |
| SCHEMBL27704997 | 0.77 | BCAT2 (0.59) | BCAT2KEAP1NFE2L2PARP1IKBKB | |
| SCHEMBL8517076 | 0.76 | BCAT2 (0.44) | BCAT2KEAP1NFE2L2PARP1IKBKB | |
| SCHEMBL6903281 | 0.76 | BCAT2 (0.44) | BCAT2KEAP1NFE2L2PARP1F2 | |
| SCHEMBL28853128 | 0.76 | TSHR (0.54) | KEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970216-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014151616-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2014-09-25 | — | — | WO | disclosed |