Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 12/20 | 0.53 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 4/20 | 0.37 |
| ▸ | BRAF | P15056 | 4/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.36 |
| ▸ | ADCK1 | Q86TW2 | 1/20 | 0.36 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3265187 | 0.88 | MAP2K1 (0.55) | MAP2K1FLT1MKNK1RAF1BRAF | |
| SCHEMBL13522225 | 0.85 | MAP2K1 (0.52) | MAP2K1FLT1MKNK1RAF1BRAF | |
| SCHEMBL1578880 | 0.83 | MAP2K1 (0.51) | MAP2K1FLT1MAP2K2CHEK1MAPK10 | |
| SCHEMBL3265182 | 0.83 | MAP2K1 (0.61) | MAP2K1CSF1RMAP2K2 | |
| SCHEMBL2294850 | 0.80 | MAP2K1 (0.49) | MAP2K1FLT1MKNK1BRAFMAP2K2 | |
| SCHEMBL16103842 | 0.80 | MAP2K1 (0.60) | MAP2K1FLT1MAP2K2 | |
| SCHEMBL12423788 | 0.78 | MAP2K1 (0.51) | MAP2K1FLT1METAP2MAP2K2CHEK1 | |
| SCHEMBL16070018 | 0.75 | MAP2K1 (0.60) | MAP2K1FLT1MAP2K2 | |
| SCHEMBL2295504 | 0.74 | MAP2K1 (0.81) | MAP2K1BRAFMAP2K2 | |
| SCHEMBL13522214 | 0.73 | MAP2K1 (0.60) | MAP2K1MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8841462-B2 | Bicyclic heterocycles as MEK kinase inhibitors | GENENTECH, INC. | 2014-09-23 | — | — | US | disclosed |