Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 12/20 | 0.55 |
| ▸ | FLT1 | P17948 | 1/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 3/20 | 0.37 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.37 |
| ▸ | RAF1 | P04049 | 2/20 | 0.37 |
| ▸ | BRAF | P15056 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16103816 | 0.88 | MAP2K1 (0.53) | MAP2K1FLT1MKNK1CSF1RMAP2K2 | |
| SCHEMBL3265182 | 0.85 | MAP2K1 (0.61) | MAP2K1CSF1RMAP2K2NUDT1 | |
| SCHEMBL13522225 | 0.84 | MAP2K1 (0.52) | MAP2K1FLT1MKNK1CSF1RMAP2K2 | |
| SCHEMBL1578880 | 0.83 | MAP2K1 (0.51) | MAP2K1FLT1MAP2K2 | |
| SCHEMBL2294850 | 0.80 | MAP2K1 (0.49) | MAP2K1FLT1MKNK1MAP2K2BRAF | |
| SCHEMBL16070018 | 0.79 | MAP2K1 (0.60) | MAP2K1FLT1MAP2K2 | |
| SCHEMBL345623 | 0.78 | MAP2K1 (0.52) | MAP2K1FLT1MAP2K2 | |
| SCHEMBL16103842 | 0.77 | MAP2K1 (0.60) | MAP2K1FLT1MAP2K2 | |
| SCHEMBL12423788 | 0.77 | MAP2K1 (0.51) | MAP2K1FLT1MAP2K2METAP2 | |
| SCHEMBL2295504 | 0.75 | MAP2K1 (0.81) | MAP2K1MAP2K2BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8841462-B2 | Bicyclic heterocycles as MEK kinase inhibitors | GENENTECH, INC. | 2014-09-23 | — | — | US | disclosed |
| WO-2010003025-A1 | BICYCLIC HETEROCYCLES AS MEK KINASE INHIBITORS | GENENTECH, INC. (US) | 2010-01-07 | — | — | WO | disclosed |