Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 17/20 | 0.61 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.45 |
| ▸ | CSF1R | P07333 | 3/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3265187 | 0.85 | MAP2K1 (0.55) | MAP2K1MAP2K2CSF1RNUDT1 | |
| SCHEMBL16103816 | 0.83 | MAP2K1 (0.53) | MAP2K1MAP2K2CSF1R | |
| SCHEMBL13522225 | 0.82 | MAP2K1 (0.52) | MAP2K1MAP2K2CSF1R | |
| SCHEMBL1578880 | 0.80 | MAP2K1 (0.51) | MAP2K1MAP2K2 | |
| SCHEMBL2954977 | 0.80 | MAP2K1 (0.69) | MAP2K1MAP2K2CA2 | |
| SCHEMBL2294850 | 0.77 | MAP2K1 (0.49) | MAP2K1MAP2K2 | |
| SCHEMBL2295504 | 0.77 | MAP2K1 (0.81) | MAP2K1MAP2K2 | |
| SCHEMBL2726111 | 0.77 | MAP2K1 (0.71) | MAP2K1CA2 | |
| SCHEMBL12423788 | 0.77 | MAP2K1 (0.51) | MAP2K1MAP2K2 | |
| SCHEMBL1579837 | 0.74 | MAP2K1 (0.70) | MAP2K1MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010003025-A1 | BICYCLIC HETEROCYCLES AS MEK KINASE INHIBITORS | GENENTECH, INC. (US) | 2010-01-07 | — | — | WO | disclosed |