Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 3/20 | 0.35 |
| ▸ | BUB1 | O43683 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.32 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 1/20 | 0.30 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL850275 | 0.85 | CA2 (0.43) | CA2ALDH1A1NPSR1NAMPTBUB1 | |
| SCHEMBL850274 | 0.85 | CA2 (0.43) | CA2ALDH1A1NPSR1NAMPTBUB1 | |
| SCHEMBL13555139 | 0.79 | CA2 (0.40) | CA2ALDH1A1NPSR1NAMPTBUB1 | |
| SCHEMBL11976713 | 0.71 | CA2 (0.44) | CA2ALDH1A1NPSR1NAMPTBUB1 | |
| SCHEMBL3461796 | 0.70 | MAPT (0.49) | CA2ALDH1A1NAMPTKDM4EHSD17B10 | |
| SCHEMBL10758903 | 0.70 | CA2 (0.40) | CA2ALDH1A1NPSR1NAMPTBUB1 | |
| SCHEMBL10758894 | 0.70 | CA2 (0.40) | CA2ALDH1A1NPSR1NAMPTBUB1 | |
| SCHEMBL10759549 | 0.70 | CA2 (0.40) | CA2ALDH1A1NPSR1NAMPTBUB1 | |
| SCHEMBL10758908 | 0.70 | CA2 (0.40) | CA2ALDH1A1NPSR1NAMPTBUB1 | |
| SCHEMBL10759878 | 0.70 | CA2 (0.40) | CA2ALDH1A1NPSR1NAMPTBUB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2433940-B9 | SPIROIMIDAZOLONE DERIVATIVE | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2015-10-28 | — | — | EP | disclosed |
| EP-2433940-B1 | SPIROIMIDAZOLONE DERIVATIVE | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2014-09-24 | — | — | EP | disclosed |