Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 2/20 | 0.48 |
| ▸ | MMP12 | P39900 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1609495 | 0.91 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2MMP2MMP12TSHR | |
| SCHEMBL534139 | 0.89 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2MMP2MMP12TSHR | |
| SCHEMBL534570 | 0.88 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2MMP2MMP12TSHR | |
| SCHEMBL16636936 | 0.76 | HDAC3 (0.54) | ALDH1A1SMN1; SMN2MMP2MMP12TSHR | |
| SCHEMBL6508653 | 0.74 | TSHR (0.67) | ALDH1A1SMN1; SMN2MMP2MMP12TSHR | |
| Trifluoroacetic Acid SCHEMBL27579421 | 0.71 | TSHR (0.62) | ALDH1A1TSHRCES1 | |
| SCHEMBL9738326 | 0.71 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2MMP2MMP12TSHR | |
| SCHEMBL9738316 | 0.71 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2MMP2MMP12TSHR | |
| SCHEMBL9738613 | 0.70 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2MMP2MMP12TSHR | |
| SCHEMBL3268152 | 0.70 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2MMP2MMP12TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9340526-B2 | Process for preparing pyridyl-substituted pyrazoles | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-05-17 | — | — | US | disclosed |
| US-20150191447-A1 | Process for Preparing Pyridyl-Substituted Pyrazoles | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-07-09 | — | — | US | disclosed |
| US-8987460-B2 | Process for preparing pyridyl-substituted pyrazoles | BAYER CROPSCIENCE AG (DE) | 2015-03-24 | — | — | US | disclosed |
| EP-2414345-B1 | Method for manufacturing Pyridyl-substituted pyrazoles | BAYER CROPSCIENCE AG (DE) | 2014-09-17 | — | — | EP | disclosed |
| US-20130131347-A1 | Process for Preparing Pyridyl-Substituted Pyrazoles | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-05-23 | — | — | US | disclosed |
| US-8362261-B2 | Process for preparing pyridyl-substituted pyrazoles | BAYER CROPSCIENCE AG (DE) | 2013-01-29 | — | — | US | disclosed |
| US-20120136156-A2 | PROCESS FOR PREPARING PYRIDYL-SUBSTITUTED PYRAZOLES | BAYER CROPSCIENCE AG (DE) | 2012-05-31 | — | — | US | disclosed |
| US-20110087029-A1 | Process for Preparing Pyridyl-Substituted Pyrazoles | BAYER CROPSCIENCE AG (DE) | 2011-04-14 | — | — | US | disclosed |
| EP-2243777-A1 | Method for manufacturing Pyridyl-substituted pyrazoles | Bayer CropScience AG (DE) | 2010-10-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130131347-A1 | Process for Preparing Pyridyl-Substituted Pyrazoles | PDXK, PLK2, WNK3 | ALDH1A1 715/4885SMN1; SMN2 4424/4885MMP2 3741/4885 |
| US-20150191447-A1 | Process for Preparing Pyridyl-Substituted Pyrazoles | PDXK, PLK2, WNK3 | ALDH1A1 715/4885SMN1; SMN2 4424/4885MMP2 3741/4885 |
| US-20110087029-A1 | Process for Preparing Pyridyl-Substituted Pyrazoles | PDXK, PLK2, WNK3 | ALDH1A1 715/4885SMN1; SMN2 4424/4885MMP2 3741/4885 |
| US-20120136156-A2 | PROCESS FOR PREPARING PYRIDYL-SUBSTITUTED PYRAZOLES | PDXK, PLK2, WNK3 | ALDH1A1 715/4885SMN1; SMN2 4424/4885MMP2 3741/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.