SCHEMBL16107302

SCHEMBL16107302

COC(=S)NC[C@H]1CN(c2ccc(N3CC[Si](C)(C)CC3)c(F)c2)C(=O)O1

nearest known ligand 0.62

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MAOB P27338 8/20 0.62
MAOA P21397 4/20 0.62
LMNA P02545 1/20 0.62
PTGS1 P23219 1/20 0.62
CALML3 P27482 1/20 0.62
SDHA P31040 1/20 0.62
F10 P00742 11/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16107303 1.00 MAOB (0.62) MAOBMAOALMNAPTGS1CALML3
SCHEMBL17975537 0.92 MAOB (0.64) MAOBMAOALMNAPTGS1CALML3
SCHEMBL17975536 0.92 MAOB (0.64) MAOBMAOALMNAPTGS1CALML3
SCHEMBL16133370 0.91 MAOB (0.65) MAOBMAOALMNAPTGS1CALML3
SCHEMBL10152699 0.91 MAOB (0.65) MAOBMAOALMNAPTGS1CALML3
SCHEMBL13159169 0.90 MAOB (0.66) MAOBMAOALMNAPTGS1CALML3
SCHEMBL17975539 0.89 MAOB (0.67) MAOBMAOALMNAPTGS1CALML3
SCHEMBL14861831 0.89 MAOA (0.79) MAOBMAOALMNAPTGS1CALML3
SCHEMBL17975538 0.89 MAOB (0.67) MAOBMAOALMNAPTGS1CALML3
SCHEMBL14861828 0.89 MAOA (0.79) MAOBMAOALMNAPTGS1CALML3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2766373-B1 SILA ANALOGS OF OXAZOLIDINONE DERIVATIVES AND SYNTHESIS THEREOF COUNCIL SCIENT IND RES (IN) 2016-08-17 EP claimed
US-9233989-B2 Sila analogs of oxazolidinone derivatives and synthesis thereof COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2016-01-12 US claimed
US-20140296133-A1 SILA ANALOGS OF OXAZOLIDINONE DERIVATIVES AND SYNTHESIS THEREOF COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2014-10-02 US claimed
EP-2766373-B1 SILA ANALOGS OF OXAZOLIDINONE DERIVATIVES AND SYNTHESIS THEREOF COUNCIL SCIENT IND RES (IN) 2016-08-17 EP disclosed
EP-2766373-B1 SILA ANALOGS OF OXAZOLIDINONE DERIVATIVES AND SYNTHESIS THEREOF COUNCIL SCIENT IND RES (IN) 2016-08-17 EP disclosed
US-9233989-B2 Sila analogs of oxazolidinone derivatives and synthesis thereof COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2016-01-12 US disclosed
US-9233989-B2 Sila analogs of oxazolidinone derivatives and synthesis thereof COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2016-01-12 US disclosed
US-8877355-B2 Monoamine compound, charge-transporting material, and organic electroluminescent device MITSUBISHI CHEMICAL CORPORATION (JP) 2014-11-04 US disclosed
US-20140296133-A1 SILA ANALOGS OF OXAZOLIDINONE DERIVATIVES AND SYNTHESIS THEREOF COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2014-10-02 US disclosed
US-20140296133-A1 SILA ANALOGS OF OXAZOLIDINONE DERIVATIVES AND SYNTHESIS THEREOF COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2014-10-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140296133-A1 SILA ANALOGS OF OXAZOLIDINONE DERIVATIVES AND SYNTHESIS THEREOF STS, F2, TFPI MAOB 2316/4885MAOA 788/4885LMNA 1239/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.