SCHEMBL16133370

SCHEMBL16133370

COC(=O)NC[C@H]1CN(c2ccc(N3CC[Si](C)(C)CC3)c(F)c2)C(=O)O1

nearest known ligand 0.65

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ MAOB P27338 7/20 0.65
▸ MAOA P21397 4/20 0.65
▸ PTGS1 P23219 2/20 0.65
▸ SDHA P31040 2/20 0.65
▸ LMNA P02545 1/20 0.65
▸ CALML3 P27482 1/20 0.65
▸ F10 P00742 11/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16107302 0.91 MAOB (0.62) MAOBMAOAPTGS1SDHALMNA
SCHEMBL16107303 0.91 MAOB (0.62) MAOBMAOAPTGS1SDHALMNA
SCHEMBL17975538 0.91 MAOB (0.67) MAOBMAOAPTGS1SDHALMNA
SCHEMBL17975539 0.91 MAOB (0.67) MAOBMAOAPTGS1SDHALMNA
SCHEMBL14861828 0.91 MAOA (0.79) MAOBMAOAPTGS1SDHALMNA
SCHEMBL14861831 0.91 MAOA (0.79) MAOBMAOAPTGS1SDHALMNA
SCHEMBL17975535 0.90 MAOB (0.66) MAOBMAOAPTGS1SDHALMNA
SCHEMBL14872040 0.89 MAOB (0.65) MAOBMAOAPTGS1SDHALMNA
SCHEMBL18408947 0.89 MAOB (0.82) MAOBMAOAPTGS1SDHALMNA
SCHEMBL17975536 0.88 MAOB (0.64) MAOBMAOAPTGS1SDHALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9233989-B2 Sila analogs of oxazolidinone derivatives and synthesis thereof COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2016-01-12 — — US disclosed
US-20140296133-A1 SILA ANALOGS OF OXAZOLIDINONE DERIVATIVES AND SYNTHESIS THEREOF COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2014-10-02 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140296133-A1 SILA ANALOGS OF OXAZOLIDINONE DERIVATIVES AND SYNTHESIS THEREOF STS, F2, TFPI MAOB 2316/4885MAOA 788/4885PTGS1 1202/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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