SCHEMBL16112159

SCHEMBL16112159

COC(=O)C1(CCO[Si](C)(C)C(C)(C)C)CCSCC1

nearest known ligand 0.36

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CYP4F2 P78329 1/20 0.36
CYP4A11 Q02928 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5895665 0.80 PKM (0.34) CYP4F2CYP4A11
SCHEMBL5895249 0.77 PKM (0.47) CYP4F2CYP4A11
SCHEMBL21628327 0.74 PPM1D (0.31)
SCHEMBL16142012 0.74 CYP4F2 (0.45) CYP4F2CYP4A11
SCHEMBL15863342 0.73
SCHEMBL23246690 0.73 PKM (0.43) CYP4F2CYP4A11
SCHEMBL16573785 0.71 HSD11B1 (0.35)
SCHEMBL20617478 0.71 CYP4F2 (0.50) CYP4F2CYP4A11
SCHEMBL20713831 0.71 CYP3A4 (0.34) CYP4F2CYP4A11
SCHEMBL15863491 0.71 CYP4F2 (0.30) CYP4F2CYP4A11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2014160649-A1 HYDROXAMIC ACID DERIVATIVES AS LPXC INHIBITORS FOR THE TREATMENT OF BACTERIAL INFECTIONS NOVARTIS AG (CH) 2014-10-02 WO disclosed
WO-2014160649-A1 HYDROXAMIC ACID DERIVATIVES AS LPXC INHIBITORS FOR THE TREATMENT OF BACTERIAL INFECTIONS NOVARTIS AG (CH) 2014-10-02 WO disclosed