Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.53 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.53 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.53 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.53 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.53 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.53 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.53 |
| ▸ | KDR | P35968 | 2/20 | 0.50 |
| ▸ | PLK4 | O00444 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.50 |
| ▸ | INSR | P06213 | 1/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.50 |
| ▸ | FLT1 | P17948 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
| ▸ | MARK3 | P27448 | 1/20 | 0.50 |
| ▸ | FLT4 | P35916 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16112700 | 0.88 | PRKAB2 (0.49) | PRKAB1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL16112341 | 0.86 | PLK4 (0.47) | PRKAB1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL19611368 | 0.86 | PLK4 (0.47) | PRKAB1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL16112343 | 0.86 | PLK4 (0.47) | PRKAB1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL19611367 | 0.86 | PLK4 (0.47) | PRKAB1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL16112600 | 0.83 | PLK4 (0.47) | PRKAB1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL17531648 | 0.82 | PRKAB1 (0.56) | PRKAB1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL16111465 | 0.76 | PRKAB1 (0.52) | PRKAB1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL16111471 | 0.75 | RET (0.52) | PRKAB1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL16111470 | 0.75 | RET (0.52) | PRKAB1PRKAB2PRKAG1PRKAA2PRKAA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970311-A2 | BMP INHIBITORS AND METHODS OF USE THEREOF | The Brigham and Women's Hospital, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014160203-A2 | BMP INHIBITORS AND METHODS OF USE THEREOF | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2014-10-02 | — | — | WO | disclosed |