Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT6A | Q92794 | 12/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | G6PD | P11413 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 2/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL873113 | 0.82 | MAPT (0.53) | KAT6AMAPTKMT2AKDM4EALDH1A1 | |
| SCHEMBL14964128 | 0.82 | MAPT (0.49) | KAT6AMAPTKMT2AKDM4EALDH1A1 | |
| SCHEMBL526836 | 0.78 | ALDH1A1 (0.47) | KAT6AMAPTKMT2AKDM4EALDH1A1 | |
| SCHEMBL552775 | 0.77 | LMNA (0.47) | KAT6AMAPTKMT2AKDM4EALDH1A1 | |
| SCHEMBL31057726 | 0.75 | KDM4E (0.44) | KAT6AMAPTKMT2AKDM4EALDH1A1 | |
| SCHEMBL16787410 | 0.75 | KAT6A (0.46) | KAT6AMAPTKMT2AKDM4EALDH1A1 | |
| SCHEMBL387290 | 0.75 | MAPT (0.47) | KAT6AMAPTKMT2AKDM4EALDH1A1 | |
| SCHEMBL6209994 | 0.75 | MAPT (0.43) | KAT6AMAPTKMT2AKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL30710779 | 0.74 | KDM4E (0.43) | KAT6AMAPTKMT2AKDM4EALDH1A1 | |
| SCHEMBL540011 | 0.74 | NOTUM (0.58) | MAPTKMT2AKDM4EALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2989100-A1 | NAPHTHYRIDINE DERIVATIVES USEFUL AS ALPHA-V-BETA-6 INTEGRIN ANTAGONISTS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2016-03-02 | — | — | EP | disclosed |
| WO-2014154725-A1 | NAPHTHYRIDINE DERIVATIVES USEFUL AS ALPHA-V-BETA-6 INTEGRIN ANTAGONISTS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2014-10-02 | — | — | WO | disclosed |