Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A2 | P11168 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PSD | A5PKW4 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8193697 | 0.88 | TARBP2 (0.46) | MAPTKDM4ESMN1; SMN2RXFP1LMNA | |
| SCHEMBL19781271 | 0.84 | TARBP2 (0.47) | MAPTKDM4ESMN1; SMN2RXFP1LMNA | |
| SCHEMBL28790079 | 0.80 | TARBP2 (0.43) | MAPTKDM4ESMN1; SMN2RXFP1LMNA | |
| SCHEMBL28836532 | 0.79 | TARBP2 (0.43) | MAPTKDM4ESMN1; SMN2RXFP1ALDH1A1 | |
| SCHEMBL30099163 | 0.79 | TARBP2 (0.43) | MAPTKDM4ESMN1; SMN2RXFP1LMNA | |
| SCHEMBL1851116 | 0.78 | PTGS1 (0.67) | MAPTKDM4ESMN1; SMN2RXFP1TARBP2 | |
| SCHEMBL6223693 | 0.76 | MAPK1 (0.63) | MAPTKDM4ESMN1; SMN2RXFP1ALDH1A1 | |
| SCHEMBL16793371 | 0.74 | PSMD14 (0.44) | SMN1; SMN2ALDH1A1LMNAPTGS1PTGS2 | |
| SCHEMBL23099627 | 0.74 | NPC1 (0.50) | MAPTKDM4ESMN1; SMN2RXFP1ALDH1A1 | |
| SCHEMBL2263014 | 0.74 | KDM4E (0.46) | MAPTKDM4ESMN1; SMN2RXFP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014155300-A2 | SUBSTITUED PYRIMIDINE AMINE DERIVATIVES AS TAK-1 INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2014-10-02 | — | — | WO | disclosed |
| WO-2014155300-A2 | SUBSTITUED PYRIMIDINE AMINE DERIVATIVES AS TAK-1 INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2014-10-02 | — | — | WO | disclosed |