Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 4/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 2/20 | 0.39 |
| ▸ | CCR3 | P51677 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.37 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16118654 | 0.82 | KMT2A (0.51) | KMT2ALMNASMN1; SMN2CCR3NPC1 | |
| SCHEMBL16118659 | 0.82 | KMT2A (0.51) | KMT2ALMNASMN1; SMN2CCR3NPC1 | |
| SCHEMBL16118656 | 0.79 | KMT2A (0.40) | KMT2ALMNAALDH1A1 | |
| SCHEMBL13543091 | 0.74 | ATM (0.49) | POLBKMT2ARAB9ATPSAB1TPSD1 | |
| SCHEMBL4321273 | 0.68 | CHRM1 (0.42) | KMT2AKDM1ACHRM1CHRM3MAOB | |
| SCHEMBL4321271 | 0.68 | CHRM1 (0.42) | KMT2AKDM1ACHRM1CHRM3MAOB | |
| SCHEMBL12512207 | 0.68 | KDM4E (0.50) | NPC1ALDH1A1 | |
| SCHEMBL3482988 | 0.67 | EPHX2 (0.55) | POLBGAASMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL12511407 | 0.67 | KDM4E (0.46) | KMT2AALDH1A1 | |
| SCHEMBL12511541 | 0.67 | KDM4E (0.46) | KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9796674-B2 | Benzyl urea derivatives for activating TGF-beta signaling | THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS | 2017-10-24 | — | — | US | disclosed |
| US-20160039756-A1 | BENZYL UREA DERIVATIVES FOR ACTIVATING TGF-BETA SIGNALING | The Board of Trustees of the Leladn Stanford Junior University (US) | 2016-02-11 | — | — | US | disclosed |
| US-20160039756-A1 | BENZYL UREA DERIVATIVES FOR ACTIVATING TGF-BETA SIGNALING | The Board of Trustees of the Leladn Stanford Junior University (US) | 2016-02-11 | — | — | US | disclosed |
| WO-2014152869-A2 | BENZYL UREA DERIVATIVES FOR ACTIVATING TGF-BETA SIGNALING | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2014-09-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160039756-A1 | BENZYL UREA DERIVATIVES FOR ACTIVATING TGF-BETA SIGNALING | TGFBR1, TGFB1, TGFBR2 | POLB 285/4885KMT2A 2008/4885EGFR 831/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.