Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.43 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.43 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | FPR1 | P21462 | 1/20 | 0.40 |
| ▸ | FPR2 | P25090 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1493414 | 0.88 | HSD11B1 (0.45) | SMN1; SMN2MEN1KMT2AHSD11B1TSHR | |
| SCHEMBL1612925 | 0.86 | SMN1; SMN2 (0.47) | SMN1; SMN2MEN1KMT2AKCNJ6KCNJ5 | |
| SCHEMBL1612525 | 0.85 | ALDH1A1 (0.52) | MEN1KMT2ATSHRALDH1A1HTT | |
| SCHEMBL1612568 | 0.85 | ALDH1A1 (0.44) | MEN1KMT2AHSD11B1TSHRALDH1A1 | |
| SCHEMBL1493574 | 0.78 | TP53 (0.41) | SMN1; SMN2HSD11B1ALDH1A1HTTPKM | |
| SCHEMBL1612419 | 0.76 | HSD11B1 (0.43) | HSD11B1ALDH1A1TP53 | |
| SCHEMBL1493380 | 0.76 | MAPT (0.45) | MEN1KMT2AHSD11B1ALDH1A1HTT | |
| SCHEMBL1493310 | 0.76 | ALDH1A1 (0.42) | SMN1; SMN2HSD11B1TSHRALDH1A1HTT | |
| SCHEMBL1493469 | 0.74 | MAPT (0.44) | SMN1; SMN2KMT2ATSHRALDH1A1HTT | |
| SCHEMBL1612000 | 0.73 | HTT (0.45) | SMN1; SMN2ALDH1A1HTTTP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110086889-A1 | TETRAZOLE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110086889-A1 | TETRAZOLE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | HCRTR2, HCRTR1, NPY1R | SMN1; SMN2 4215/4885MEN1 683/4885KMT2A 1510/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.