Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT6 | Q96LA8 | 5/20 | 0.69 |
| ▸ | PRMT8 | Q9NR22 | 4/20 | 0.69 |
| ▸ | PRMT1 | Q99873 | 5/20 | 0.67 |
| ▸ | PRMT3 | O60678 | 3/20 | 0.67 |
| ▸ | CARM1 | Q86X55 | 3/20 | 0.67 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16125825 | 0.88 | PRMT6 (0.53) | PRMT6PRMT8PRMT1PRMT3CARM1 | |
| SCHEMBL16128993 | 0.86 | PRMT1 (0.57) | PRMT6PRMT8PRMT1PRMT3CARM1 | |
| SCHEMBL16201164 | 0.86 | PRMT6 (0.50) | PRMT6PRMT8PRMT1PRMT3CARM1 | |
| SCHEMBL16201183 | 0.85 | PRMT1 (0.50) | PRMT6PRMT8PRMT1PRMT3CARM1 | |
| SCHEMBL16125821 | 0.84 | PRMT6 (0.48) | PRMT6PRMT8PRMT1PRMT3CARM1 | |
| SCHEMBL16201239 | 0.83 | PRMT6 (0.47) | PRMT6PRMT8PRMT1PRMT3CARM1 | |
| SCHEMBL16201213 | 0.83 | CARM1 (0.48) | PRMT6PRMT8PRMT1PRMT3CARM1 | |
| SCHEMBL16201176 | 0.83 | PRMT6 (0.51) | PRMT6PRMT8PRMT1PRMT3CARM1 | |
| SCHEMBL16201236 | 0.83 | PRMT6 (0.51) | PRMT6PRMT8PRMT1PRMT3CARM1 | |
| SCHEMBL16121394 | 0.83 | PRMT6 (0.51) | PRMT6PRMT8PRMT1PRMT3CARM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970134-B1 | PYRAZOLE DERIVATIVES AS PRMT1 INHIBITORS AND USES THEREOF | EPIZYME INC (US) | 2018-02-28 | — | — | EP | disclosed |
| US-20160039767-A1 | PYRAZOLE DERIVATIVES AS PRMT1 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2016-02-11 | — | — | US | disclosed |
| US-8952026-B2 | PRMT1 inhibitors and uses thereof | Epizyme, Inc. (US) | 2015-02-10 | — | — | US | disclosed |
| WO-2014153090-A1 | PYRAZOLE DERIVATIVES ASPRMT1 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2014-09-25 | — | — | WO | disclosed |
| US-20140288140-A1 | PRMT1 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2014-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160039767-A1 | PYRAZOLE DERIVATIVES AS PRMT1 INHIBITORS AND USES THEREOF | PRMT1, PRMT3, PRMT5 | PRMT6 5/4885PRMT8 6/4885PRMT1 1/4885 |
| US-20140288140-A1 | PRMT1 INHIBITORS AND USES THEREOF | PRMT1, PRMT3, PRMT6 | PRMT6 3/4885PRMT8 6/4885PRMT1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.