Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | GAA | P10253 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | CCR1 | P32246 | 5/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | CCR2 | P41597 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16128082 | 1.00 | KDM4E (0.65) | KDM4EGAAMAPTCCR1CHRM2 | |
| SCHEMBL16128279 | 1.00 | KDM4E (0.65) | KDM4EGAAMAPTCCR1CHRM2 | |
| SCHEMBL16128162 | 0.86 | KDM4E (0.50) | KDM4EGAAMAPTCCR1CHRM2 | |
| SCHEMBL16101072 | 0.82 | OPRM1 (0.46) | KDM4EGAAMAPTCCR1OPRM1 | |
| SCHEMBL16101500 | 0.82 | OPRM1 (0.46) | KDM4EGAAMAPTCCR1OPRM1 | |
| SCHEMBL16128163 | 0.82 | ALOX15 (0.46) | KDM4EGAAMAPTCCR1OPRM1 | |
| SCHEMBL16128161 | 0.82 | OPRM1 (0.45) | KDM4EGAAMAPTCCR1OPRM1 | |
| SCHEMBL16128224 | 0.82 | KDM4E (0.48) | KDM4EGAAMAPTCCR1CHRM2 | |
| SCHEMBL18361300 | 0.81 | HDAC1 (0.52) | — | |
| SCHEMBL23016005 | 0.80 | KDM4E (1.00) | KDM4EGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9656994-B2 | Substituted benzimidazoles as nociceptin receptor modulators | THE SCRIPPS RESEARCH INSTITUTE (US) | 2017-05-23 | — | — | US | disclosed |
| WO-2014153529-A1 | SUBSTITUTED BENZIMIDAZOLES AS NOCICEPTIN RECEPTOR MODULATORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2014-09-25 | — | — | WO | disclosed |