Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LIN28A | Q9H9Z2 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4854669 | 0.85 | TDP1 (0.58) | TDP1MAPTSMN1; SMN2LIN28AKDM4E | |
| SCHEMBL4033092 | 0.78 | TDP1 (0.74) | TDP1MAPTSMN1; SMN2LIN28AKDM4E | |
| SCHEMBL16099570 | 0.78 | CYP1A2 (0.51) | TDP1MAPTSMN1; SMN2LIN28AKDM4E | |
| SCHEMBL5182246 | 0.77 | L3MBTL1 (0.42) | TDP1MAPTSMN1; SMN2LIN28AKDM4E | |
| SCHEMBL27219673 | 0.76 | TDP1 (0.71) | TDP1MAPTSMN1; SMN2LIN28AKDM4E | |
| SCHEMBL4961822 | 0.76 | TDP1 (0.63) | TDP1MAPTSMN1; SMN2LIN28AKDM4E | |
| SCHEMBL8772399 | 0.74 | TDP1 (0.81) | TDP1MAPTSMN1; SMN2LIN28AKDM4E | |
| SCHEMBL23495440 | 0.73 | TDP1 (0.78) | TDP1MAPTSMN1; SMN2LIN28AKDM4E | |
| SCHEMBL31384028 | 0.72 | TDP1 (0.59) | TDP1MAPTSMN1; SMN2LIN28AKDM4E | |
| SCHEMBL7105171 | 0.71 | SMN1; SMN2 (0.57) | TDP1MAPTSMN1; SMN2LIN28AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014146749-A2 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2014-09-25 | — | — | WO | disclosed |