Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 10/20 | 0.59 |
| ▸ | SIRT2 | Q8IXJ6 | 7/20 | 0.59 |
| ▸ | CNR1 | P21554 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | XBP1 | P17861 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA4 | P22748 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12961110 | 0.89 | HTT (0.61) | CNR1KDM4EHTTPOLBMAPT | |
| SCHEMBL9280415 | 0.87 | CNR1 (0.60) | CNR1KDM4EHTTMEN1RAB9A | |
| SCHEMBL15605878 | 0.87 | CNR1 (0.52) | SIRT1SIRT2CNR1KDM4EHTT | |
| SCHEMBL15344370 | 0.84 | NAMPT (0.56) | SIRT1SIRT2HTTPOLB | |
| SCHEMBL9970321 | 0.84 | CNR1 (0.58) | CNR1KDM4EHTTMEN1RAB9A | |
| SCHEMBL14873812 | 0.84 | KMT2A (0.61) | CNR1KDM4EHTTMEN1RAB9A | |
| SCHEMBL14608288 | 0.84 | HTT (0.56) | CNR1KDM4EHTTPOLBMAPT | |
| SCHEMBL16383171 | 0.84 | HTT (0.56) | CNR1HTTPOLBRAB9AKMT2A | |
| SCHEMBL15829520 | 0.82 | CNR1 (0.59) | CNR1KDM4EHTTMEN1RAB9A | |
| SCHEMBL15532876 | 0.82 | CNR1 (0.63) | CNR1KDM4EHTTMEN1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2766474-B1 | INHIBITION AND ENHANCEMENT OF REPROGRAMMING BY CHROMATIN MODIFYING ENZYMES | CHILDRENS MEDICAL CENTER (US) | 2020-10-07 | — | — | EP | disclosed |
| EP-2646441-B1 | CARBOCYCLE-SUBSTITUTED PURINE AND 7-DEAZAPURINE COMPOUNDS | EPIZYME INC (US) | 2015-12-02 | — | — | EP | disclosed |
| WO-2014153001-A1 | COMBINATION THERAPY FOR TREATING CANCER | Epizyme, Inc. (US) | 2014-09-25 | — | — | WO | disclosed |