Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 4/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GYS1 | P13807 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1613006 | 1.00 | CYP2D6 (0.48) | CYP2D6CYP2C19HTTCYP2C9CYP3A4 | |
| SCHEMBL289842 | 0.84 | P2RX7 (0.51) | P2RX7SIGMAR1GYS1 | |
| SCHEMBL7217950 | 0.84 | HTT (0.48) | CYP2D6CYP2C19HTTCYP2C9CYP3A4 | |
| SCHEMBL289410 | 0.84 | P2RX7 (0.51) | P2RX7SIGMAR1GYS1 | |
| SCHEMBL1613178 | 0.83 | HTT (0.65) | CYP2D6CYP2C19HTTCYP2C9CYP3A4 | |
| SCHEMBL16601374 | 0.83 | P2RX7 (0.59) | CYP2D6CYP2C19HTTCYP2C9CYP3A4 | |
| SCHEMBL289312 | 0.83 | HTT (0.65) | CYP2D6CYP2C19HTTCYP2C9CYP3A4 | |
| SCHEMBL16601376 | 0.83 | P2RX7 (0.59) | CYP2D6CYP2C19HTTCYP2C9CYP3A4 | |
| SCHEMBL19974980 | 0.83 | P2RX7 (0.62) | CYP2D6CYP2C19HTTCYP2C9CYP3A4 | |
| SCHEMBL30062891 | 0.83 | P2RX7 (0.62) | CYP2D6CYP2C19HTTCYP2C9CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9527811-B2 | Carboxamide compounds and their use as calpain inhibitors | AbbVie Deutschland GmbH & Co. KG (DE) | 2016-12-27 | — | — | US | disclosed |
| CN-105732581-A | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS IV | ABBVIE 公司 | 2016-07-06 | — | — | CN | disclosed |
| US-20150252017-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS V | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-09-10 | — | — | US | disclosed |
| US-9051304-B2 | Carboxamide compounds and their use as calpain inhibitors V | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-06-09 | — | — | US | disclosed |
| US-9018206-B2 | Carboxamide compounds and their use as calpain inhibitors | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-04-28 | — | — | US | disclosed |
| US-20150099786-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-04-09 | — | — | US | disclosed |
| CN-102933548-B | Carboxamide compounds and their use as calpain inhibitors | ABBOTT LAB | 2015-03-11 | — | — | CN | disclosed |
| EP-2516393-B1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | ABBVIE DEUTSCHLAND (DE) | 2014-10-29 | — | — | EP | disclosed |
| US-20140179702-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS IV | AbbVie Deutschland GmbH & Co. KG (DE) | 2014-06-26 | — | — | US | disclosed |
| US-8598211-B2 | Carboxamide compounds and their use as calpain inhibitors IV | ABBVIE INC. (US) | 2013-12-03 | — | — | US | disclosed |
| CN-102933548-A | Carboxamide compounds and their use as calpain inhibitors | ABBOTT GMBH & CO KG | 2013-02-13 | — | — | CN | disclosed |
| EP-2516415-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS IV | Abbott GmbH & Co. KG (DE) | 2012-10-31 | — | — | EP | disclosed |
| EP-2516393-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | Abbott GmbH & Co. KG (DE) | 2012-10-31 | — | — | EP | disclosed |
| CN-102753541-A | Carboxamide compounds and their use as calpain inhibitors iv | ABBOTT GMBH & CO KG | 2012-10-24 | — | — | CN | disclosed |
| US-8283363-B2 | Carboxamide compounds and their use as calpain inhibitors | ABBOTT LABORATORIES (US) | 2012-10-09 | — | — | US | disclosed |
| WO-2011076812-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS IV | ABBOTT GMBH & CO. KG (DE) | 2011-06-30 | — | — | WO | disclosed |
| WO-2011076811-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | ABBOTT GMBH & CO. KG (DE) | 2011-06-30 | — | — | WO | disclosed |
| US-20110152325-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS IV | ABBOTT GMBH & CO. KG (DE) | 2011-06-23 | — | — | US | disclosed |
| US-20110152265-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS V | ABBOTT GMBH & CO. KG (DE) | 2011-06-23 | — | — | US | disclosed |
| US-20110086879-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | ABBOTT GMBH & CO. KG (DE) | 2011-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150252017-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS V | CAPN2, CAPN1, CAPNS1 | CYP2D6 2654/4885CYP2C19 3026/4885HTT 335/4885 |
| US-20140179702-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS IV | CAPN2, CAPNS1, CAPN1 | CYP2D6 3608/4885CYP2C19 3650/4885HTT 824/4885 |
| US-20110152325-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS IV | CAPN2, CAPN1, CAPN9 | CYP2D6 2686/4885CYP2C19 3007/4885HTT 528/4885 |
| US-20110152265-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS V | CAPN2, CAPN1, CAPNS1 | CYP2D6 2654/4885CYP2C19 3026/4885HTT 335/4885 |
| US-20110086879-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | CAPN1, CAPN2, CAPNS1 | CYP2D6 2751/4885CYP2C19 2606/4885HTT 408/4885 |
| US-20150099786-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | CAPN1, CAPN2, CAPNS1 | CYP2D6 2751/4885CYP2C19 2606/4885HTT 408/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.