Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.35 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.35 |
| ▸ | TTR | P02766 | 2/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.35 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6036998 | 0.85 | LCK (0.50) | LCKPTGS2CYP1A1TTRALOX5 | |
| SCHEMBL6036997 | 0.85 | LCK (0.50) | LCKPTGS2CYP1A1TTRALOX5 | |
| SCHEMBL16406665 | 0.78 | LCK (0.38) | LCKPTGS2CYP1A1TTRALOX5 | |
| SCHEMBL10281914 | 0.78 | ALDH1A1 (0.39) | LCKPTGS2CYP1A1TTRALOX5 | |
| SCHEMBL18648430 | 0.74 | MIF (0.35) | LCKPTGS2CYP1A1TTRALOX5 | |
| SCHEMBL18648535 | 0.72 | PTGS2 (0.48) | PTGS2KDM4EMAPTMEN1ALDH1A1 | |
| SCHEMBL15686516 | 0.69 | PTGS2 (0.68) | PTGS2CYP1A1TTRALOX5CYP1B1 | |
| SCHEMBL15258559 | 0.68 | KDM4E (0.69) | LCKPTGS2CYP1A1TTRALOX5 | |
| SCHEMBL17506713 | 0.66 | BACE1 (0.50) | LCKPTGS2CYP1A1TTRALOX5 | |
| SCHEMBL23986064 | 0.66 | MAPT (0.55) | TTRKDM4EMAPTMEN1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8846724-B2 | Compositions for treating obesity and insulin resistance disorders | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-09-30 | — | — | US | disclosed |