Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | CASP1 | P29466 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18291646 | 0.91 | ALDH1A1 (0.50) | MAP4K4ALDH1A1SMN1; SMN2HTTCYP3A4 | |
| SCHEMBL13279548 | 0.84 | MAP4K4 (0.57) | MAP4K4ALDH1A1SMN1; SMN2HTTCYP3A4 | |
| SCHEMBL13466376 | 0.84 | MAP4K4 (0.48) | MAP4K4ALDH1A1SMN1; SMN2HTTSMPD3 | |
| SCHEMBL11981452 | 0.80 | ALDH1A1 (0.64) | ALDH1A1SMN1; SMN2HTTCNR2KDM4E | |
| Ammonia Solution, Strong SCHEMBL27696045 | 0.78 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2HTTCNR2KDM4E | |
| SCHEMBL20249266 | 0.78 | MAP4K4 (0.42) | MAP4K4ALDH1A1SMN1; SMN2HTTCYP3A4 | |
| SCHEMBL18291244 | 0.75 | MAP4K4 (0.47) | MAP4K4ALDH1A1SMN1; SMN2HTTCYP3A4 | |
| SCHEMBL1781248 | 0.75 | MAP4K4 (0.53) | MAP4K4ALDH1A1SMN1; SMN2HTTCYP2C9 | |
| SCHEMBL15651882 | 0.75 | MAP4K4 (0.59) | MAP4K4ALDH1A1SMN1; SMN2HTTCYP2C9 | |
| SCHEMBL10289476 | 0.75 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2HTTCNR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140288044-A1 | COMPOSITIONS AND THERAPEUTIC USES OF IKK-RELATED KINASE EPSILON AND TANKBINDING KINASE 1 INHIBITORS | ALZHEIMER'S INSTITUTE OF AMERICA, INC. (US) | 2014-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140288044-A1 | COMPOSITIONS AND THERAPEUTIC USES OF IKK-RELATED KINASE EPSILON AND TANKBINDING KINASE 1 INHIBITORS | CSNK1G1, PRKCE, PHKG1 | MAP4K4 295/4885ALDH1A1 4487/4885SMN1; SMN2 3119/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.