Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
| ▸ | FABP3 | P05413 | 2/20 | 0.34 |
| ▸ | FABP4 | P15090 | 2/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.34 |
| ▸ | P2RX2 | Q9UBL9 | 3/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.33 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.32 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | TTK | P33981 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL799306 | 0.80 | PIK3CA (0.38) | P2RX3P2RX2PIK3CAMTORALDH1A1 | |
| SCHEMBL12736481 | 0.80 | RECQL (0.33) | P2RX3P2RX2PIK3CAPIK3R1MTOR | |
| SCHEMBL15292546 | 0.80 | PIK3R1 (0.36) | P2RX3P2RX2PIK3CAPIK3R1RORC | |
| SCHEMBL16248217 | 0.78 | CRHR1 (0.35) | P2RX3P2RX2MAPTCASP1ALDH1A1 | |
| SCHEMBL10141619 | 0.78 | PIK3CA (0.42) | P2RX3P2RX2PIK3CAPIK3R1MTOR | |
| SCHEMBL12089821 | 0.78 | SMN1; SMN2 (0.39) | P2RX3P2RX2PIK3CARORCMAPT | |
| SCHEMBL83967 | 0.78 | MAPT (0.50) | P2RX3P2RX2PIK3CAPIK3R1MTOR | |
| SCHEMBL10141659 | 0.78 | GABRA1 (0.38) | GABRA1GABRB2MAPTCASP1AURKA | |
| SCHEMBL11890406 | 0.78 | TSHR (0.43) | GABRA1P2RX3P2RX2PIK3CAPIK3R1 | |
| SCHEMBL115578 | 0.78 | PIK3R1 (0.40) | P2RX3P2RX2PIK3CAPIK3R1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9738653-B2 | Fused furans for the treatment of hepatitis C | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-08-22 | — | — | US | disclosed |
| EP-2970174-B1 | FUSED FURANS FOR THE TREATMENT OF HEPATITIS C | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |
| WO-2014159559-A1 | FUSED FURANS FOR THE TREATMENT OF HEPATITIS C | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-10-02 | — | — | WO | disclosed |