Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT5B | Q4FZB7 | 2/20 | 0.81 |
| ▸ | KMT5C | Q86Y97 | 2/20 | 0.81 |
| ▸ | NSD2 | O96028 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | CCR1 | P32246 | 1/20 | 0.56 |
| ▸ | FERMT2 | Q96AC1 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9271568 | 1.00 | KMT5B (0.81) | KMT5BKMT5CNSD2CYP2D6CYP2C19 | |
| SCHEMBL9540195 | 1.00 | KMT5B (0.81) | KMT5BKMT5CNSD2CYP2D6CYP2C19 | |
| SCHEMBL9267916 | 0.97 | KMT5B (0.76) | KMT5BKMT5CNSD2CYP2D6CYP2C19 | |
| SCHEMBL4810793 | 0.93 | KMT5B (0.71) | KMT5BKMT5CNSD2CYP2D6CYP2C19 | |
| SCHEMBL30817045 | 0.92 | KMT5B (0.70) | KMT5BKMT5CNSD2CYP2D6CYP2C19 | |
| SCHEMBL30817039 | 0.92 | KMT5B (0.70) | KMT5BKMT5CNSD2CYP2D6CYP2C19 | |
| SCHEMBL7837345 | 0.92 | KMT5B (0.70) | KMT5BKMT5CNSD2CYP2D6CYP2C19 | |
| SCHEMBL30817065 | 0.92 | KMT5B (0.70) | KMT5BKMT5CNSD2CYP2D6CYP2C19 | |
| SCHEMBL7826415 | 0.92 | KMT5B (0.70) | KMT5BKMT5CNSD2CYP2D6CYP2C19 | |
| SCHEMBL7205744 | 0.90 | KMT5B (0.67) | KMT5BKMT5CNSD2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160058749-A1 | TREATMENTS FOR NEUROPATHY | CHILDRENS MEDICAL CENTER (US) | 2016-03-03 | — | — | US | disclosed |
| US-20160045487-A1 | COMPOSITIONS AND METHODS FOR TREATING NEUROPATHY | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-02-18 | — | — | US | disclosed |
| US-20110086878-A1 | Treatments for Neuropathy | NIH-DEITR | 2011-04-14 | — | — | US | disclosed |
| US-7863295-B2 | Treatments for neuropathy | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2011-01-04 | — | — | US | disclosed |
| US-20090203735-A1 | TREATMENTS FOR NEUROPATHY | NIH-DEITR | 2009-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160058749-A1 | TREATMENTS FOR NEUROPATHY | NGF, BDNF, NTRK2 | KMT5B 2884/4885KMT5C 3348/4885NSD2 3911/4885 |
| US-20090203735-A1 | TREATMENTS FOR NEUROPATHY | NGF, BDNF, NTRK2 | KMT5B 2884/4885KMT5C 3348/4885NSD2 3911/4885 |
| US-20160045487-A1 | COMPOSITIONS AND METHODS FOR TREATING NEUROPATHY | PMP22, GAP43, NGF | KMT5B 1424/4885KMT5C 2069/4885NSD2 4548/4885 |
| US-20110086878-A1 | Treatments for Neuropathy | NGF, BDNF, NTRK2 | KMT5B 2884/4885KMT5C 3348/4885NSD2 3911/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.