Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK4 | Q16654 | 1/20 | 0.58 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.49 |
| ▸ | GRM1 | Q13255 | 10/20 | 0.48 |
| ▸ | GRM5 | P41594 | 9/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16135232 | 0.87 | PDK4 (0.52) | PDK4PDE10AGRM1GRM5HTR6 | |
| SCHEMBL16107306 | 0.86 | PDK4 (0.40) | PDK4PDE10A | |
| SCHEMBL14591413 | 0.84 | PDK4 (0.61) | PDK4PDE10AGRM1GRM5HTR6 | |
| SCHEMBL4251137 | 0.84 | CNR1 (0.50) | PDK4PDE10AGRM1GRM5HTR6 | |
| SCHEMBL31639861 | 0.83 | PDK4 (0.53) | PDK4GRM1GRM5HTR6JAK1 | |
| SCHEMBL19097424 | 0.82 | PDK4 (0.53) | PDK4GRM1GRM5HTR6JAK1 | |
| SCHEMBL31288575 | 0.82 | GRM1 (0.57) | PDK4PDE10AGRM1GRM5HTR6 | |
| SCHEMBL16422787 | 0.82 | GRM1 (0.57) | PDK4PDE10AGRM1GRM5HTR6 | |
| SCHEMBL24394241 | 0.81 | PDK4 (0.57) | PDK4PDE10AGRM1GRM5HTR6 | |
| SCHEMBL31082802 | 0.81 | HTR6 (0.48) | PDK4GRM1GRM5HTR6JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140296528-A1 | 4-ARYL-1-(BIARYLMETHYLENE) PIPERIDINE COMPOUNDS | KING ABDULAZIZ CITY FOR SCIENCE AND TECHNOLOGY (SA) | 2014-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140296528-A1 | 4-ARYL-1-(BIARYLMETHYLENE) PIPERIDINE COMPOUNDS | HTR2C, HTR3C, HTR1D | PDK4 1790/4885PDE10A 2943/4885GRM1 317/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.