Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | MIF | P14174 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | RXRB | P28702 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | RXRG | P48443 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28189813 | 0.94 | KMT2A (0.43) | LMNAKMT2AMEN1TDP1NR1H4 | |
| SCHEMBL2658114 | 0.90 | ALDH1A1 (0.44) | KMT2APKMMIFMAPTALDH1A1 | |
| SCHEMBL11999249 | 0.90 | ALDH1A1 (0.44) | KMT2APKMMIFMAPTALDH1A1 | |
| SCHEMBL2658111 | 0.90 | ALDH1A1 (0.44) | KMT2APKMMIFMAPTALDH1A1 | |
| SCHEMBL5196952 | 0.79 | AKR1C1 (0.56) | LMNAHTTKMT2AMEN1TDP1 | |
| SCHEMBL9371236 | 0.74 | ALDH1A1 (0.50) | LMNATDP1RXRARXRBALDH1A1 | |
| SCHEMBL9371234 | 0.74 | ALDH1A1 (0.50) | LMNATDP1RXRARXRBALDH1A1 | |
| SCHEMBL8114187 | 0.74 | NPC1 (0.51) | LMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL8114190 | 0.74 | NPC1 (0.51) | LMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL452233 | 0.73 | PTGS1 (0.60) | LMNAKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2786985-B1 | Antagonists of the glucagon receptor | METABASIS THERAPEUTICS INC (US) | 2018-11-28 | — | — | EP | disclosed |
| CN-101610995-B | Glucagon receptor antagonists | 症变治疗公司 | 2017-08-08 | — | — | CN | disclosed |
| EP-2786985-A2 | Antagonists of the glucagon receptor | Metabasis Therapeutics, Inc. (US) | 2014-10-08 | — | — | EP | disclosed |