Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.74 |
| ▸ | CA1 | P00915 | 5/20 | 0.59 |
| ▸ | CA9 | Q16790 | 5/20 | 0.59 |
| ▸ | CA12 | O43570 | 3/20 | 0.59 |
| ▸ | CA2 | P00918 | 3/20 | 0.58 |
| ▸ | CA4 | P22748 | 2/20 | 0.58 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.58 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.58 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | GFER | P55789 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.52 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | PTGES | O14684 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9564302 | 0.90 | POLB (0.68) | NPSR1CA1CA9CA12CA2 | |
| SCHEMBL12311922 | 0.86 | ALDH1A1 (0.63) | NPSR1CA1CA9CA12CA2 | |
| SCHEMBL20513018 | 0.86 | POLB (0.65) | NPSR1CA1CA9CA12CA2 | |
| SCHEMBL9803534 | 0.85 | LPAR1 (0.77) | NPSR1CA1CA9CA12CA2 | |
| SCHEMBL10606077 | 0.84 | NPSR1 (0.69) | NPSR1CA1CA9CA12CA2 | |
| SCHEMBL25161442 | 0.83 | CA9 (0.65) | NPSR1CA1CA9CA12CA2 | |
| SCHEMBL26227651 | 0.82 | CA1 (0.61) | CA1CA9CA12CA2CA4 | |
| SCHEMBL5010660 | 0.82 | ALDH1A1 (0.70) | NPSR1CA1CA9CA12CA2 | |
| SCHEMBL5010584 | 0.81 | CA9 (0.85) | NPSR1CA1CA9CA12CA2 | |
| SCHEMBL9339007 | 0.81 | CA9 (0.77) | NPSR1CA1CA9CA12CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10064842-B2 | KCNQ channels as therapeutic targets | WASHINGTON UNIVERSITY (US) | 2018-09-04 | — | — | US | disclosed |
| US-20160228411-A1 | KCNQ CHANNELS AS THERAPEUTIC TARGETS | WASHINGTON UNIVERSITY (US) | 2016-08-11 | — | — | US | disclosed |
| US-9345688-B2 | KCNQ channels as therapeutic targets | WASHINGTON UNIVERSITY (US) | 2016-05-24 | — | — | US | disclosed |
| US-20140303226-A1 | KCNQ CHANNELS AS THERAPEUTIC TARGETS | WASHINGTON UNIVERSITY (US) | 2014-10-09 | — | — | US | disclosed |