Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.70 |
| ▸ | ESR1 | P03372 | 1/20 | 0.68 |
| ▸ | CA1 | P00915 | 6/20 | 0.67 |
| ▸ | CA9 | Q16790 | 6/20 | 0.67 |
| ▸ | CA2 | P00918 | 3/20 | 0.67 |
| ▸ | CA4 | P22748 | 2/20 | 0.67 |
| ▸ | CA12 | O43570 | 3/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.64 |
| ▸ | MET | P08581 | 1/20 | 0.62 |
| ▸ | GFER | P55789 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12311922 | 0.94 | ALDH1A1 (0.63) | ALDH1A1ESR1CA1CA9CA2 | |
| SCHEMBL16127953 | 0.91 | CA9 (0.69) | ALDH1A1ESR1CA1CA9CA2 | |
| SCHEMBL17951022 | 0.90 | ALDH1A1 (0.72) | ALDH1A1ESR1CA1CA9CA2 | |
| SCHEMBL26227651 | 0.89 | CA1 (0.61) | ALDH1A1ESR1CA1CA9CA2 | |
| SCHEMBL12895855 | 0.89 | MET (0.72) | ALDH1A1ESR1CA1CA9CA2 | |
| SCHEMBL9564302 | 0.88 | POLB (0.68) | ALDH1A1CA1CA9CA2CA4 | |
| SCHEMBL9339007 | 0.88 | CA9 (0.77) | ALDH1A1CA1CA9CA2CA4 | |
| SCHEMBL4234750 | 0.86 | CA9 (0.77) | ALDH1A1CA1CA9CA2CA4 | |
| SCHEMBL9516311 | 0.86 | HSD17B10 (0.77) | ALDH1A1CA1CA9CA2CA4 | |
| SCHEMBL13044940 | 0.86 | ALDH1A1 (0.67) | ALDH1A1ESR1CA1CA9CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7319098-B2 | 1,3-dioxoisoindole derivatives having selective antagonism of T-type calcium channel | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2008-01-15 | — | — | US | disclosed |
| US-20070259867-A1 | 1,3-DIOXOISOINDOLE DERIVATIVES HAVING SELECTIVE ANTAGONISM OF T-TYPE CALCIUM CHANNEL | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY | 2007-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070259867-A1 | 1,3-DIOXOISOINDOLE DERIVATIVES HAVING SELECTIVE ANTAGONISM OF T-TYPE CALCIUM CHANNEL | CACNA1I, CACNA1G, CACNA1H | ALDH1A1 2648/4885ESR1 2464/4885CA1 636/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.