Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | NPY5R | Q15761 | 10/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.49 |
| ▸ | NPY2R | P49146 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8728560 | 1.00 | GAA (0.67) | GAANPY5RKMT2AMEN1ALDH1A1 | |
| SCHEMBL8728663 | 1.00 | GAA (0.67) | GAANPY5RKMT2AMEN1ALDH1A1 | |
| SCHEMBL25409408 | 0.85 | GAA (0.80) | GAANPY5RALDH1A1KDM4EAOC3 | |
| SCHEMBL5804993 | 0.85 | GAA (0.80) | GAANPY5RALDH1A1KDM4EAOC3 | |
| SCHEMBL4992458 | 0.85 | GAA (0.80) | GAANPY5RALDH1A1KDM4EAOC3 | |
| SCHEMBL8153290 | 0.85 | NPY5R (0.78) | GAANPY5RALDH1A1KDM4EAOC3 | |
| SCHEMBL9067935 | 0.83 | GAA (0.60) | GAANPY5RKMT2AMEN1ALDH1A1 | |
| SCHEMBL6223855 | 0.81 | GAA (0.74) | GAANPY5RALDH1A1KDM4EAOC3 | |
| SCHEMBL3447214 | 0.81 | GAA (0.74) | GAANPY5RALDH1A1KDM4EAOC3 | |
| SCHEMBL3447213 | 0.81 | GAA (0.74) | GAANPY5RALDH1A1KDM4EAOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180356421-A9 | Small-Molecule Hydrophobic Tagging of Fusion Proteins and Induced Degradation of Same | UNIV YALE (US) | 2018-12-13 | — | — | US | disclosed |
| US-10145848-B2 | Small-molecule hydrophobic tagging of fusion proteins and induced degradation of same | YALE UNIVERSITY (US) | 2018-12-04 | — | — | US | disclosed |
| US-20170307614-A1 | Small-Molecule Hydrophobic Tagging of Fusion Proteins and Induced Degradation of Same | UNIV YALE (US) | 2017-10-26 | — | — | US | disclosed |
| US-9632089-B2 | Small-molecule hydrophobic tagging of fusion proteins and induced degradation of same | YALE UNIVERSITY (US) | 2017-04-25 | — | — | US | disclosed |
| US-20170067874-A1 | Small-Molecule Hydrophobic Tagging of Fusion Proteins and Induced Degradation of Same | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-03-09 | — | — | US | disclosed |
| US-9500653-B2 | Small-molecule hydrophobic tagging of fusion proteins and induced degradation of same | YALE UNIVERSITY (US) | 2016-11-22 | — | — | US | disclosed |
| US-20140302523-A1 | Small-Molecule Hydrophobic Tagging of Fusion Proteins and Induced Degradation of Same | YALE UNIVERSITY (US) | 2014-10-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180356421-A9 | Small-Molecule Hydrophobic Tagging of Fusion Proteins and Induced Degradation of Same | HSP90B1, LAMP2, PSMG3 | GAA 538/4885NPY5R 4732/4885KMT2A 3767/4885 |
| US-10145848-B2 | Small-molecule hydrophobic tagging of fusion proteins and induced degradation of same | HSP90B1, LAMP2, PSMG3 | GAA 538/4885NPY5R 4732/4885KMT2A 3767/4885 |
| US-20170067874-A1 | Small-Molecule Hydrophobic Tagging of Fusion Proteins and Induced Degradation of Same | HSP90B1, LAMP2, PSMG3 | GAA 532/4885NPY5R 4726/4885KMT2A 3792/4885 |
| US-20170307614-A1 | Small-Molecule Hydrophobic Tagging of Fusion Proteins and Induced Degradation of Same | HSP90B1, LAMP2, PSMG3 | GAA 538/4885NPY5R 4732/4885KMT2A 3767/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.