Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | KDM4A | O75164 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | GLS | O94925 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16405266 | 0.91 | SLC7A5 (0.49) | HIF1AKDM4ANAMPTL3MBTL1SERPINE1 | |
| SCHEMBL21711869 | 0.90 | NOTUM (0.47) | HIF1AKDM4ANAMPTL3MBTL1SERPINE1 | |
| SCHEMBL8129924 | 0.90 | HDAC1 (0.40) | HIF1AKDM4ANAMPTL3MBTL1SERPINE1 | |
| SCHEMBL3877931 | 0.90 | GRM2 (0.41) | HIF1AKDM4ANAMPTL3MBTL1SERPINE1 | |
| SCHEMBL21712030 | 0.88 | NOTUM (0.51) | KDM4ANAMPTL3MBTL1SERPINE1HDAC1 | |
| SCHEMBL16147999 | 0.86 | HDAC1 (0.46) | KDM4ANAMPTL3MBTL1HDAC1MEN1 | |
| SCHEMBL879574 | 0.85 | LOXL2 (0.56) | HIF1AKDM4ANAMPTGLSLOXL2 | |
| SCHEMBL13055397 | 0.85 | KDM4A (0.51) | KDM4ANAMPTL3MBTL1HDAC1LMNA | |
| SCHEMBL1206337 | 0.84 | NAMPT (0.55) | NAMPTL3MBTL1HDAC1ALDH1A1LMNA | |
| SCHEMBL18019821 | 0.84 | DYRK1A (0.50) | KDM4ANAMPTL3MBTL1HDAC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10344060-B2 | Potent and selective inhibitors of Nav1.7 | AMGEN INC. (US) | 2019-07-09 | — | — | US | disclosed |
| US-10344060-B2 | Potent and selective inhibitors of Nav1.7 | AMGEN INC. (US) | 2019-07-09 | — | — | US | disclosed |
| EP-2970408-B1 | POTENT AND SELECTIVE INHIBITORS OF NAV1.7 | AMGEN INC (US) | 2018-01-10 | — | — | EP | disclosed |
| US-9636418-B2 | Potent and selective inhibitors of NAV1.7 | AMGEN INC. (US) | 2017-05-02 | — | — | US | disclosed |
| US-9636418-B2 | Potent and selective inhibitors of NAV1.7 | AMGEN INC. (US) | 2017-05-02 | — | — | US | disclosed |
| US-20160024159-A1 | POTENT AND SELECTIVE INHIBITORS OF NAV1.7 | AMGEN INC. (US) | 2016-01-28 | — | — | US | disclosed |
| US-20160024159-A1 | POTENT AND SELECTIVE INHIBITORS OF NAV1.7 | AMGEN INC. (US) | 2016-01-28 | — | — | US | disclosed |
| EP-2970408-A2 | POTENT AND SELECTIVE INHIBITORS OF Nav1.7 | Amgen Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| US-20150023988-A1 | POTENT AND SELECTIVE INHIBITORS OF NAV1.7 | AMGEN INC. (US) | 2015-01-22 | — | — | US | disclosed |
| US-20150023988-A1 | POTENT AND SELECTIVE INHIBITORS OF NAV1.7 | AMGEN INC. (US) | 2015-01-22 | — | — | US | disclosed |
| WO-2014165277-A2 | POTENT AND SELECTIVE INHIBITORS OF Nav1.7 | AMGEN INC. (US) | 2014-10-09 | — | — | WO | disclosed |
| WO-2014165277-A2 | POTENT AND SELECTIVE INHIBITORS OF Nav1.7 | AMGEN INC. (US) | 2014-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10344060-B2 | Potent and selective inhibitors of Nav1.7 | SCN7A, SCN9A, SCN1A | HIF1A 3622/4885KDM4A 2034/4885NAMPT 1056/4885 |
| US-20150023988-A1 | POTENT AND SELECTIVE INHIBITORS OF NAV1.7 | SCN7A, SCN9A, SCN1A | HIF1A 3622/4885KDM4A 2034/4885NAMPT 1056/4885 |
| US-20160024159-A1 | POTENT AND SELECTIVE INHIBITORS OF NAV1.7 | SCN7A, SCN9A, SCN1A | HIF1A 3622/4885KDM4A 2034/4885NAMPT 1056/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.