Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.51 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.51 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.51 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.51 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.51 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.51 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.51 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.51 |
| ▸ | ALPI | P09923 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | XIAP | P98170 | 1/20 | 0.47 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16148135 | 1.00 | TAAR1 (0.51) | TAAR1GRIK1GRIA2GRIA1GRIA3 | |
| SCHEMBL29400795 | 0.83 | SLC7A5 (0.65) | GRIA2ALPIPKMPTGS1XIAP | |
| SCHEMBL14935980 | 0.83 | SLC7A5 (0.65) | GRIA2ALPIPKMPTGS1XIAP | |
| SCHEMBL29567654 | 0.83 | SLC7A5 (0.65) | GRIA2ALPIPKMPTGS1XIAP | |
| SCHEMBL44026 | 0.83 | SLC7A5 (0.65) | GRIA2ALPIPKMPTGS1XIAP | |
| SCHEMBL44027 | 0.83 | SLC7A5 (0.65) | GRIA2ALPIPKMPTGS1XIAP | |
| SCHEMBL6377902 | 0.82 | MAOA (0.55) | GRIK1GRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL31369826 | 0.82 | GRIA2 (0.59) | TAAR1GRIK1GRIA2GRIA1GRIA3 | |
| SCHEMBL31370062 | 0.82 | MAOA (0.55) | GRIK1GRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL27634017 | 0.82 | GRIA2 (0.59) | TAAR1GRIK1GRIA2GRIA1GRIA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10344060-B2 | Potent and selective inhibitors of Nav1.7 | AMGEN INC. (US) | 2019-07-09 | — | — | US | disclosed |
| EP-2970408-B1 | POTENT AND SELECTIVE INHIBITORS OF NAV1.7 | AMGEN INC (US) | 2018-01-10 | — | — | EP | disclosed |
| US-20160024159-A1 | POTENT AND SELECTIVE INHIBITORS OF NAV1.7 | AMGEN INC. (US) | 2016-01-28 | — | — | US | disclosed |
| EP-2970408-A2 | POTENT AND SELECTIVE INHIBITORS OF Nav1.7 | Amgen Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014165277-A2 | POTENT AND SELECTIVE INHIBITORS OF Nav1.7 | AMGEN INC. (US) | 2014-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10344060-B2 | Potent and selective inhibitors of Nav1.7 | SCN7A, SCN9A, SCN1A | TAAR1 2165/4885GRIK1 404/4885GRIA2 1017/4885 |
| US-20160024159-A1 | POTENT AND SELECTIVE INHIBITORS OF NAV1.7 | SCN7A, SCN9A, SCN1A | TAAR1 2165/4885GRIK1 404/4885GRIA2 1017/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.