Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 3/20 | 0.69 |
| ▸ | MAOB | P27338 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 8/20 | 0.52 |
| ▸ | RAB9A | P51151 | 8/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14693936 | 0.83 | MAOB (0.54) | APPMAOBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14693807 | 0.82 | MAOB (0.65) | APPMAOBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14693835 | 0.80 | MAOB (0.56) | APPMAOBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14693861 | 0.80 | MAOB (0.57) | APPMAOBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13351692 | 0.79 | MAOB (0.70) | APPMAOBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1615277 | 0.79 | APP (0.66) | APPMAOBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11644349 | 0.79 | MAOB (0.55) | APPMAOBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14486171 | 0.78 | APP (0.44) | APPMAOBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13904223 | 0.78 | MAOB (0.48) | APPMAOBNPC1RAB9ATP53 | |
| SCHEMBL1614965 | 0.76 | APP (0.61) | APPMAOBNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560008-B1 | Pharmaceutical compositions for preventing or treating degenerative brain disease and method of screening the same | KOREA INST SCI & TECH (KR) | 2016-11-30 | — | — | EP | disclosed |
| EP-2560008-B1 | Pharmaceutical compositions for preventing or treating degenerative brain disease and method of screening the same | KOREA INST SCI & TECH (KR) | 2016-11-30 | — | — | EP | disclosed |
| US-9469653-B2 | Pharmaceutical compositions for preventing or treating degenerative brain disease and method of screening the same | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2016-10-18 | — | — | US | disclosed |
| US-9469653-B2 | Pharmaceutical compositions for preventing or treating degenerative brain disease and method of screening the same | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2016-10-18 | — | — | US | disclosed |
| EP-2300481-B1 | NOVEL SUBSTITUTED AZABENZOXAZOLES | MERCK SHARP & DOHME (US) | 2015-09-30 | — | — | EP | disclosed |
| EP-2300481-B1 | NOVEL SUBSTITUTED AZABENZOXAZOLES | MERCK SHARP & DOHME (US) | 2015-09-30 | — | — | EP | disclosed |
| US-20140142089-A1 | PHARMACEUTICAL COMPOSITIONS FOR PREVENTING OR TREATING DEGENERATIVE BRAIN DISEASE AND METHOD OF SCREENING THE SAME | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2014-05-22 | — | — | US | disclosed |
| US-20140142089-A1 | PHARMACEUTICAL COMPOSITIONS FOR PREVENTING OR TREATING DEGENERATIVE BRAIN DISEASE AND METHOD OF SCREENING THE SAME | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2014-05-22 | — | — | US | disclosed |
| US-8530483-B2 | Substituted azabenzoxazoles | MERCK SHARP & DOHME CORP. (US) | 2013-09-10 | — | — | US | disclosed |
| US-8530483-B2 | Substituted azabenzoxazoles | MERCK SHARP & DOHME CORP. (US) | 2013-09-10 | — | — | US | disclosed |
| EP-2560008-A2 | Pharmaceutical compositions for preventing or treating degenerative brain disease and method of screening the same | Korea Institute of Science and Technology (KR) | 2013-02-20 | — | — | EP | disclosed |
| EP-2560008-A2 | Pharmaceutical compositions for preventing or treating degenerative brain disease and method of screening the same | Korea Institute of Science and Technology (KR) | 2013-02-20 | — | — | EP | disclosed |
| US-20110212031-A1 | NOVEL SUBSTITUTED AZABENZOXAZOLES | MERCK SHARP & DOHME CORP. | 2011-09-01 | — | — | US | disclosed |
| US-20110212031-A1 | NOVEL SUBSTITUTED AZABENZOXAZOLES | MERCK SHARP & DOHME CORP. | 2011-09-01 | — | — | US | disclosed |
| US-20110212031-A1 | NOVEL SUBSTITUTED AZABENZOXAZOLES | MERCK SHARP & DOHME CORP. | 2011-09-01 | — | — | US | disclosed |
| US-20110085985-A1 | NOVEL SUBSTITUTED AZABENZOXAZOLES | MERCK SHARP & DOHME LLC | 2011-04-14 | — | — | US | disclosed |
| US-20110085985-A1 | NOVEL SUBSTITUTED AZABENZOXAZOLES | MERCK SHARP & DOHME LLC | 2011-04-14 | — | — | US | disclosed |
| US-20110085985-A1 | NOVEL SUBSTITUTED AZABENZOXAZOLES | MERCK SHARP & DOHME LLC | 2011-04-14 | — | — | US | disclosed |
| WO-2010051196-A1 | NOVEL SUBSTITUTED AZABENZOXAZOLES | MERCK SHARP & DOHME CORP. (US) | 2010-05-06 | — | — | WO | disclosed |
| WO-2009155017-A2 | NOVEL SUBSTITUTED AZABENZOXAZOLES | MERCK & CO., INC. (US) | 2009-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140142089-A1 | PHARMACEUTICAL COMPOSITIONS FOR PREVENTING OR TREATING DEGENERATIVE BRAIN DISEASE AND METHOD OF SCREENING THE SAME | PSEN2, PSEN1, GRN | APP 11/4885MAOB 396/4885NPC1 112/4885 |
| US-20110085985-A1 | NOVEL SUBSTITUTED AZABENZOXAZOLES | APBA1, APP, BACE1 | APP 2/4885MAOB 21/4885NPC1 662/4885 |
| US-20110212031-A1 | NOVEL SUBSTITUTED AZABENZOXAZOLES | MAOB, MAOA, AANAT | APP 73/4885MAOB 1/4885NPC1 1904/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.