Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 7/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | FABP3 | P05413 | 3/20 | 0.41 |
| ▸ | FABP4 | P15090 | 3/20 | 0.41 |
| ▸ | FABP5 | Q01469 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | SPR | P35270 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | AKT2 | P31751 | 1/20 | 0.33 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31343943 | 0.89 | SCN10A (0.45) | SCN10AALDH1A1MAPK1SMN1; SMN2FABP3 | |
| SCHEMBL23779523 | 0.85 | FABP3 (0.54) | SCN10AALDH1A1MAPK1SMN1; SMN2FABP3 | |
| SCHEMBL16150727 | 0.84 | FABP3 (0.36) | SCN10AALDH1A1MAPK1SMN1; SMN2FABP3 | |
| SCHEMBL25388809 | 0.84 | SCN10A (0.53) | SCN10AALDH1A1MAPK1SMN1; SMN2FABP3 | |
| SCHEMBL30562399 | 0.84 | SCN10A (0.53) | SCN10AALDH1A1MAPK1SMN1; SMN2FABP3 | |
| SCHEMBL16148999 | 0.83 | SCN10A (0.41) | SCN10AFABP3FABP4FABP5CYP2C9 | |
| SCHEMBL24070559 | 0.81 | SPR (0.41) | SCN10AALDH1A1MAPK1SMN1; SMN2FABP3 | |
| SCHEMBL18560287 | 0.80 | SCN10A (0.42) | SCN10AALDH1A1SMN1; SMN2KCNQ2GPR35 | |
| SCHEMBL31343919 | 0.79 | SCN10A (0.43) | SCN10AALDH1A1MAPK1SMN1; SMN2FABP3 | |
| SCHEMBL21906089 | 0.76 | SCN10A (0.58) | SCN10APTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105008358-B | inhibitors of human immunodeficiency virus replication | 百时美施贵宝公司 | 2017-12-29 | — | — | CN | disclosed |
| US-9655889-B2 | Inhibitors of human immunodeficiency virus replication | VIIV Healthcare UK (No.5) Limited (GB) | 2017-05-23 | — | — | US | disclosed |
| EP-2970273-B1 | INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | VIIV HEALTHCARE UK (NO 5) LTD (GB) | 2017-03-01 | — | — | EP | disclosed |
| EP-2970273-A1 | INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | Bristol-Myers Squibb Company (US) | 2016-01-20 | — | — | EP | disclosed |
| US-20160000771-A1 | Inhibitors of Human Immunodeficiency Virus Replication | VIIV HEALTHCARE UK (NO. 5) LIMITED (GB) | 2016-01-07 | — | — | US | disclosed |
| WO-2014164409-A1 | INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160000771-A1 | Inhibitors of Human Immunodeficiency Virus Replication | EIF2AK2, RTF2, MAVS | SCN10A 4717/4885ALDH1A1 3508/4885MAPK1 1620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.