Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.48 |
| ▸ | ESR1 known ✓ | P03372 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.51 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.48 |
| ▸ | PPARG | P37231 | 7/20 | 0.48 |
| ▸ | PPARD | Q03181 | 7/20 | 0.48 |
| ▸ | PPARA | Q07869 | 7/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.48 |
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.48 |
| ▸ | TLR2 | O60603 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | FABP4 | P15090 | 2/20 | 0.48 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.48 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetradecane SCHEMBL23322531 | 1.00 | ALDH1A1 (0.65) | ALDH1A1HSPD1BLMHSPE1GPR84 | |
| Citric Acid SCHEMBL28027037 | 0.98 | ALDH1A1 (0.68) | ALDH1A1HSPD1BLMHSPE1GPR84 | |
| Citric Acid SCHEMBL875432 | 0.98 | ALDH1A1 (0.68) | ALDH1A1HSPD1BLMHSPE1GPR84 | |
| Citric Acid SCHEMBL27042357 | 0.98 | ALDH1A1 (0.68) | ALDH1A1HSPD1BLMHSPE1GPR84 | |
| Citric Acid SCHEMBL27642067 | 0.98 | ALDH1A1 (0.68) | ALDH1A1HSPD1BLMHSPE1GPR84 | |
| Citric Acid SCHEMBL10687560 | 0.98 | ALDH1A1 (0.68) | ALDH1A1HSPD1BLMHSPE1GPR84 | |
| Citric Acid SCHEMBL28044779 | 0.96 | ALDH1A1 (0.71) | ALDH1A1HSPD1BLMHSPE1GPR84 | |
| Citric Acid SCHEMBL8917064 | 0.93 | ALDH1A1 (0.68) | ALDH1A1HSPD1BLMHSPE1GPR84 | |
| Citric Acid SCHEMBL8917073 | 0.93 | ALDH1A1 (0.68) | ALDH1A1HSPD1BLMHSPE1GPR84 | |
| Citric Acid SCHEMBL9431044 | 0.91 | ALDH1A1 (0.71) | ALDH1A1HSPD1BLMHSPE1GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014164682-A1 | AZAADAMANTANE FORMATE ESTER AND PROCESS PREPARING AZAADAMANTANE DERIVATIVES | ABBVIE INC. (US) | 2014-10-09 | — | — | WO | disclosed |