Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.46 |
| ▸ | ESR1 known ✓ | P03372 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.71 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.48 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.46 |
| ▸ | PPARG | P37231 | 6/20 | 0.46 |
| ▸ | PPARD | Q03181 | 6/20 | 0.46 |
| ▸ | PPARA | Q07869 | 6/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.46 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | TLR2 | O60603 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | FABP4 | P15090 | 2/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.46 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL10687560 | 0.98 | ALDH1A1 (0.68) | ALDH1A1HSPD1BLMHSPE1GPR84 | |
| Citric Acid SCHEMBL27042357 | 0.98 | ALDH1A1 (0.68) | ALDH1A1HSPD1BLMHSPE1GPR84 | |
| Citric Acid SCHEMBL27642067 | 0.98 | ALDH1A1 (0.68) | ALDH1A1HSPD1BLMHSPE1GPR84 | |
| Citric Acid SCHEMBL875432 | 0.98 | ALDH1A1 (0.68) | ALDH1A1HSPD1BLMHSPE1GPR84 | |
| Citric Acid SCHEMBL28027037 | 0.98 | ALDH1A1 (0.68) | ALDH1A1HSPD1BLMHSPE1GPR84 | |
| Tetradecane SCHEMBL23322531 | 0.96 | ALDH1A1 (0.65) | ALDH1A1HSPD1BLMHSPE1GPR84 | |
| Citric Acid SCHEMBL16149368 | 0.96 | ALDH1A1 (0.65) | ALDH1A1HSPD1BLMHSPE1GPR84 | |
| Citric Acid SCHEMBL9431044 | 0.95 | ALDH1A1 (0.71) | ALDH1A1HSPD1BLMHSPE1AKR1B1 | |
| Citric Acid SCHEMBL8917073 | 0.93 | ALDH1A1 (0.68) | ALDH1A1HSPD1BLMHSPE1AKR1B1 | |
| Citric Acid SCHEMBL8917064 | 0.93 | ALDH1A1 (0.68) | ALDH1A1HSPD1BLMHSPE1AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105668632-A | Variable valency metal catalyzed and doped tungsten bronze nano-short rod particle and preparation method thereof | 大连工业大学 | 2016-06-15 | — | — | CN | claimed |
| CN-119395176-A | Detection method of optical isomer of citric acid Sha Zuomi | 合肥亿帆生物制药有限公司 | 2025-02-07 | — | — | CN | disclosed |
| CN-115197239-A | Preparation method and application of eribulin intermediate | 江苏恒瑞医药股份有限公司 | 2022-10-18 | — | — | CN | disclosed |
| CN-105668633-B | Sea urchin shape tungsten bronze particle prepared by a kind of utilization template and preparation method thereof | 大连工业大学 | 2017-06-23 | — | — | CN | disclosed |
| CN-105668632-B | A kind of tungsten bronze nanometer stub particle of variable valency metal catalysis and doping and preparation method thereof | 大连工业大学 | 2017-06-20 | — | — | CN | disclosed |
| CN-105502503-B | A kind of hexagonal crystal tungsten bronze nanometer stub particle and preparation method thereof | 大连工业大学 | 2017-06-20 | — | — | CN | disclosed |
| CN-105668633-A | Sea urchin-shaped tungsten bronze particle prepared with template agent and preparation method thereof | 大连工业大学 | 2016-06-15 | — | — | CN | disclosed |
| CN-105668632-A | Variable valency metal catalyzed and doped tungsten bronze nano-short rod particle and preparation method thereof | 大连工业大学 | 2016-06-15 | — | — | CN | disclosed |
| CN-105502503-A | Hexagonal crystal tungsten bronze short rod nanoparticles and preparation method thereof | UNIV DALIAN POLYTECHNIC | 2016-04-20 | — | — | CN | disclosed |