Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FASN | P49327 | 2/20 | 0.69 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.55 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.55 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.53 |
| ▸ | MTOR | P42345 | 3/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.52 |
| ▸ | USP7 | Q93009 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 2/20 | 0.46 |
| ▸ | BCR | P11274 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16149302 | 0.87 | FASN (0.64) | FASNMKNK2MKNK1PIK3CAMTOR | |
| SCHEMBL7722304 | 0.87 | DPP4 (0.54) | FASNPIK3CAMTORKCNH2PIK3CD | |
| SCHEMBL17389567 | 0.82 | FASN (1.00) | FASNMKNK2MKNK1USP7 | |
| SCHEMBL28389740 | 0.81 | FASN (0.71) | FASNHPGDPOLBALDH1A1TSHR | |
| SCHEMBL16151082 | 0.80 | FASN (0.64) | FASNMKNK2MKNK1PIK3CAMTOR | |
| SCHEMBL17389638 | 0.80 | FASN (0.64) | FASNMKNK2MKNK1PIK3CAMTOR | |
| SCHEMBL17389822 | 0.80 | FASN (0.92) | FASNMKNK2MKNK1PIK3CAUSP7 | |
| SCHEMBL21497426 | 0.79 | FASN (0.76) | FASNMKNK2MKNK1PIK3CAMTOR | |
| Trifluoroacetic Acid SCHEMBL16149057 | 0.79 | MKNK1 (0.66) | FASNMKNK2MKNK1PIK3CAMTOR | |
| Trifluoroacetic Acid SCHEMBL16150958 | 0.79 | MKNK1 (0.66) | FASNMKNK2MKNK1PIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014164767-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR INHIBITION OF FASN | FORMA THERAPEUTICS, INC. (US) | 2014-10-09 | — | — | WO | disclosed |