Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FASN | P49327 | 2/20 | 0.64 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.55 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.52 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ATR | Q13535 | 2/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.49 |
| ▸ | MTOR | P42345 | 3/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.49 |
| ▸ | CKS1B | P61024 | 1/20 | 0.47 |
| ▸ | SKP1 | P63208 | 1/20 | 0.47 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.47 |
| ▸ | USP7 | Q93009 | 1/20 | 0.47 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.47 |
| ▸ | AKT1 | P31749 | 1/20 | 0.47 |
| ▸ | GBA1 | P04062 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16149558 | 0.87 | FASN (0.69) | FASNMKNK1MKNK2PIK3CAMTOR | |
| SCHEMBL31388221 | 0.85 | FASN (0.52) | FASNMKNK2CKS1BSKP1SKP2 | |
| SCHEMBL4920109 | 0.81 | FASN (0.66) | FASNHDAC4MEN1KMT2ACRBN | |
| SCHEMBL8252454 | 0.81 | KMT2A (0.72) | FASNHDAC4MEN1KMT2ACRBN | |
| SCHEMBL18318281 | 0.81 | USP30 (0.52) | MEN1KMT2A | |
| SCHEMBL18321588 | 0.81 | HPGDS (0.46) | FASNPIK3CAMTORCKS1BSKP1 | |
| SCHEMBL30718251 | 0.81 | CKS1B (0.50) | PIK3CAMTORPIK3CDKCNH2PIK3CB | |
| SCHEMBL27029508 | 0.81 | CKS1B (0.50) | PIK3CAMTORPIK3CDKCNH2PIK3CB | |
| SCHEMBL18321768 | 0.80 | GPR119 (0.45) | FASNPIK3CAMTORCKS1BSKP1 | |
| SCHEMBL18321571 | 0.80 | HPGDS (0.45) | FASNPIK3CAMTORCKS1BSKP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014164767-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR INHIBITION OF FASN | FORMA THERAPEUTICS, INC. (US) | 2014-10-09 | — | — | WO | disclosed |