Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.54 |
| ▸ | MGAM | O43451 | 1/20 | 0.52 |
| ▸ | FASN | P49327 | 1/20 | 0.51 |
| ▸ | ACACB | O00763 | 1/20 | 0.48 |
| ▸ | ACACA | Q13085 | 1/20 | 0.48 |
| ▸ | HPGDS | O60760 | 1/20 | 0.48 |
| ▸ | CCR3 | P51677 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16149558 | 0.87 | FASN (0.69) | FASNHPGDTSHRPIK3CDPIK3CA | |
| SCHEMBL28178640 | 0.81 | SMN1; SMN2 (0.63) | DPP4MGAMFASNCCR3HPGD | |
| SCHEMBL7722174 | 0.81 | MKNK1 (0.59) | DPP4MGAMFASNACACBACACA | |
| SCHEMBL16599201 | 0.79 | OGA (0.51) | DPP4MGAMFASNACACBACACA | |
| SCHEMBL28391303 | 0.79 | TSHR (0.73) | HPGDTSHRNPC1TP53RAB9A | |
| SCHEMBL23244124 | 0.79 | LMNA (0.67) | DPP4MGAMFASNTSHRAKR1C3 | |
| SCHEMBL16599008 | 0.79 | MAOB (0.63) | DPP4MGAMFASNHPGDCAPN1 | |
| SCHEMBL16002871 | 0.79 | DPP4 (0.54) | DPP4MGAMFASNACACBACACA | |
| SCHEMBL16599203 | 0.78 | MEN1 (0.66) | MGAMCAPN1KCNH2KDM4ENPC1 | |
| SCHEMBL30791187 | 0.78 | SMN1; SMN2 (0.63) | DPP4TSHRKDM4ETP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399629-B1 | PYRROLIDINES AND PIPERIDINES FOR TREATING MICROBIAL INFECTIONS BY REDUCING EXPORT OF COADMINISTERED ANTIMICROBIAL AGENT OR COMPOUND SYNTHESIZED BY MICROBES FOR THEIR GROWTH; REDUCING IN VIVO AVAILABILITY | MICROCIDE PHARMACEUTICALS, INC. | 2002-06-04 | — | — | US | disclosed |
| WO-2000001714-A1 | EFFLUX PUMP INHIBITORS | MICROCIDE PHARMACEUTICALS, INC. (US) | 2000-01-13 | — | — | WO | disclosed |