Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | AKT2 | P31751 | 1/20 | 0.37 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL684413 | 0.87 | AKT1 (0.46) | L3MBTL1ALDH1A1HPGDHTTMAPT | |
| SCHEMBL16151958 | 0.82 | ESR1 (0.38) | L3MBTL1ATMTDP1ALDH1A1HPGD | |
| SCHEMBL16151932 | 0.78 | L3MBTL1 (0.43) | L3MBTL1TDP1ALDH1A1HPGDLMNA | |
| SCHEMBL16151907 | 0.76 | LMNA (0.40) | L3MBTL1ALDH1A1LMNASMN1; SMN2POLB | |
| SCHEMBL16151886 | 0.75 | KMT2A (0.41) | ALDH1A1NPC1RAB9AAKT1AKT2 | |
| SCHEMBL16151890 | 0.75 | KMT2A (0.41) | ALDH1A1NPC1RAB9AAKT1AKT2 | |
| SCHEMBL685406 | 0.74 | KDM4E (0.46) | L3MBTL1ALDH1A1HPGDHTTMAPT | |
| SCHEMBL2738591 | 0.74 | AKT1 (0.46) | L3MBTL1ALDH1A1HPGDHTTMAPT | |
| SCHEMBL16151906 | 0.73 | CACNA1B (0.39) | L3MBTL1ALDH1A1HTTSMN1; SMN2POLB | |
| SCHEMBL679637 | 0.73 | AKT1 (0.45) | L3MBTL1ALDH1A1HPGDHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853199-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors | ARRAY BIOPHARMA, INC. (US) | 2014-10-07 | — | — | US | disclosed |