Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HMGCR | P04035 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | SLC13A5 | Q86YT5 | 4/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | ACLY | P53396 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL7883033 | 1.00 | ALDH1A1 (0.65) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL15092997 | 1.00 | ALDH1A1 (0.65) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL9202924 | 0.98 | ALDH1A1 (0.62) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL686741 | 0.98 | ALDH1A1 (0.68) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL29157615 | 0.96 | ALDH1A1 (0.65) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL1146498 | 0.96 | ALDH1A1 (0.65) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL28783769 | 0.96 | ALDH1A1 (0.65) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL9538173 | 0.96 | ALDH1A1 (0.65) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL28657879 | 0.96 | ALDH1A1 (0.65) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL28046137 | 0.96 | ALDH1A1 (0.65) | ALDH1A1TSHRLMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6682747-B1 | STABILIZING NONSTEROIDAL ANTIINFLAMMATORIES WITH HIGHLY DISPERSED SILICON DIOXIDE USING HIGH SHEAR FORCES AND SUCH AS HYDROXYETHYL CELLULOSE | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2004-01-27 | — | — | US | claimed |
| EP-1066029-B1 | PERORAL ACTIVE AGENT SUSPENSION | BOEHRINGER INGELHEIM PHARMA (DE) | 2002-10-09 | — | — | EP | claimed |
| US-6184220-B1 | LOW VISCOSITY ACID ENOLCARBOXAMIDE NON-STEROIDAL ANTIINFLAMMATORY DRUG (NSAID) SUSPENSION STABILISED BY A LOW CONCENTRATION OF DISPERSED SILICA IN THE PRESENCE OF A WATER SOLUBLE CELLULOSE ETHER | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-02-06 | — | — | US | claimed |
| CN-102647971-B | Container for a composition comprising meloxicam | BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) | 2016-03-16 | — | — | CN | disclosed |
| US-9186296-B2 | Containers for compositions comprising meloxicam | BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) | 2015-11-17 | — | — | US | disclosed |
| US-9101529-B2 | Containers for compositions comprising meloxicam | BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) | 2015-08-11 | — | — | US | disclosed |
| US-20130161228-A1 | CONTAINERS FOR COMPOSITIONS COMPRISING MELOXICAM | BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) | 2013-06-27 | — | — | US | disclosed |
| CN-102883724-A | Use of meloxicam for the long-term treatment of kidney disorders in cats | BOEHRINGER INGELHEIM VETMED | 2013-01-16 | — | — | CN | disclosed |
| CN-102647971-A | Container for a composition comprising meloxicam | BOEHRINGER INGELHEIM VETMED | 2012-08-22 | — | — | CN | disclosed |
| US-20110218191-A1 | USE OF MELOXICAM FOR THE LONG TERM-TREATMENT OF KIDNEY DISORDERS IN CATS | BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) | 2011-09-08 | — | — | US | disclosed |
| US-20110083985-A1 | CONTAINERS FOR COMPOSITIONS COMPRISING MELOXICAM | BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) | 2011-04-14 | — | — | US | disclosed |
| US-6682747-B1 | STABILIZING NONSTEROIDAL ANTIINFLAMMATORIES WITH HIGHLY DISPERSED SILICON DIOXIDE USING HIGH SHEAR FORCES AND SUCH AS HYDROXYETHYL CELLULOSE | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2004-01-27 | — | — | US | disclosed |
| US-6184220-B1 | LOW VISCOSITY ACID ENOLCARBOXAMIDE NON-STEROIDAL ANTIINFLAMMATORY DRUG (NSAID) SUSPENSION STABILISED BY A LOW CONCENTRATION OF DISPERSED SILICA IN THE PRESENCE OF A WATER SOLUBLE CELLULOSE ETHER | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-02-06 | — | — | US | disclosed |