Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HMGCR | P04035 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | SLC13A5 | Q86YT5 | 4/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | ACLY | P53396 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL28046137 | 0.98 | ALDH1A1 (0.65) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL1615245 | 0.98 | ALDH1A1 (0.65) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL28783769 | 0.98 | ALDH1A1 (0.65) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL7883033 | 0.98 | ALDH1A1 (0.65) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL15092997 | 0.98 | ALDH1A1 (0.65) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL6048190 | 0.96 | ALDH1A1 (0.62) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL9202924 | 0.96 | ALDH1A1 (0.62) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL27890932 | 0.95 | ALDH1A1 (0.68) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL384976 | 0.95 | ALDH1A1 (0.68) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL9538173 | 0.93 | ALDH1A1 (0.65) | ALDH1A1TSHRLMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 524 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12473580-B1 | One-step method for synthesizing amoxicillin from penicillin or salt thereof through enzyme catalysis | XINGZHI COLLEGE ZHEJIANG NORMAL UNIVERSITY (CN) | 2025-11-18 | — | — | US | claimed |
| CN-120078139-A | Preparation method of coated peanuts containing black rice anthocyanin | 合肥市朕泰老爷爷食品有限公司 | 2025-06-03 | — | — | CN | claimed |
| CN-119800731-A | Printing technology of polyester fabric | 绍兴市柯桥区信和数码纺织技术有限公司 | 2025-04-11 | — | — | CN | claimed |
| CN-118995868-B | Method for synthesizing amoxicillin from penicillin or salt thereof by enzyme catalysis one-step method | 浙江师范大学行知学院 | 2025-03-28 | — | — | CN | claimed |
| CN-119506373-A | Preparation method and application of deodorized beet red | 江西丹霞生物科技股份有限公司 | 2025-02-25 | — | — | CN | claimed |
| CN-118415950-B | Moisturizing and whitening cream and preparation method thereof | 广东爱丽斯化妆品有限公司 | 2025-02-11 | — | — | CN | claimed |
| CN-116585394-B | Processing method for preparing belladonna extract by belladonna grass processing | 安徽恒达药业有限公司 | 2025-01-28 | — | — | CN | claimed |
| CN-116041623-B | Preparation method of porous starch with high oil absorption rate | 东莞东美食品有限公司 | 2025-01-28 | — | — | CN | claimed |
| CN-118048353-B | Iminoacid specific endoprotease compound enzyme preparation and preparation method thereof | 海南华研胶原科技股份有限公司 | 2024-12-03 | — | — | CN | claimed |
| CN-118995868-A | Method for synthesizing amoxicillin from penicillin or salt thereof by enzyme catalysis one-step method | 浙江师范大学行知学院 | 2024-11-22 | — | — | CN | claimed |
| CN-103203036-A | Air cleaning agent for removing formaldehyde in enclosed air of motor vehicle | SHANGHAI SHILU INFORMATION TECHNOLOGY CO LTD | 2013-07-17 | — | — | CN | claimed |
| CN-103156836-A | Nafamostat mesilate composition and preparation method thereof | NANJING CHANGAO PHARMACEUTICAL SCIENCE AND TECHNOLOGY CO LTD | 2013-06-19 | — | — | CN | claimed |
| CN-102621269-A | Detection method of pullulan | HUAYUAN MEDICAL RES INST CO LTD | 2012-08-01 | — | — | CN | claimed |
| CN-101817998-A | Method for preparing purple sweet potato pigment microcapsules | UNIV SOUTH CHINA NORMAL | 2010-09-01 | — | — | CN | claimed |
| CN-101672834-A | Method for detecting quality of Chinese medicinal preparation for treating diabetic retinopathy | ZHEJIANG WANMA PHARMACEUTICAL | 2010-03-17 | — | — | CN | claimed |
| CN-101322684-A | Acetic acid desmopressin injection prescription and preparation technique thereof | HAINAN ZHONGHE PHARMACEUTICAL (CN) | 2008-12-17 | — | — | CN | claimed |
| CN-101318011-A | Pentapeptide nose spraying agent for thymus gland, preparation method and application thereof | HAINAN ZHONGHE PHARMACEUTICAL (CN) | 2008-12-10 | — | — | CN | claimed |
| CN-1278672-C | Pharmaceutical composition for intramuscular injection containing loxoprofen | SHIN POONG PHARMACEUTICAL CO (KR) | 2006-10-11 | — | — | CN | claimed |
| CN-1121158-C | Microwave spectrophotometric process for the fast detection of nitrosamine and nitroxide content in tobacco | NANJING UNIVERSITY OF TECHNOLOGY (CN) | 2003-09-17 | — | — | CN | claimed |
| CN-1298096-A | Microwave spectrophotometric process for the fast detection of nitrosamine and nitroxide content in tobacco | NANJING UNIVERSITY OF TECHNOLOGY (CN) | 2001-06-06 | — | — | CN | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12473580-B1 | One-step method for synthesizing amoxicillin from penicillin or salt thereof through enzyme catalysis | APEH, DNPEP, PHYKPL | MEN1 3902/4885ALDH1A1 492/4885TSHR 4742/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.