Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8943361 | 0.72 | JAK2 (0.49) | — | |
| SCHEMBL21886185 | 0.69 | HPGD (0.40) | HPGDHTTHSD17B10MEN1LMNA | |
| SCHEMBL15999395 | 0.68 | JAK2 (0.49) | HPGDHTTHSD17B10MEN1KMT2A | |
| SCHEMBL25598558 | 0.67 | PTPN11 (0.39) | LMNA | |
| SCHEMBL20750091 | 0.66 | CNR1 (0.35) | MEN1LMNAKMT2A | |
| SCHEMBL18629110 | 0.65 | IDO1 (0.33) | — | |
| SCHEMBL21886254 | 0.65 | PLAU (0.38) | HPGDHTTHSD17B10MEN1LMNA | |
| SCHEMBL14612607 | 0.63 | CRHR1 (0.32) | — | |
| SCHEMBL15648351 | 0.63 | CDK2 (0.55) | MEN1KMT2A | |
| SCHEMBL19103338 | 0.63 | EGFR (0.39) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2786995-A1 | Azaindoles useful as inhibitors of JAK and other protein kinases | Vertex Pharmaceuticals Incorporated (US) | 2014-10-08 | — | — | EP | disclosed |