Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | PPARG | P37231 | 5/20 | 0.60 |
| ▸ | PPARD | Q03181 | 4/20 | 0.60 |
| ▸ | PPARA | Q07869 | 4/20 | 0.60 |
| ▸ | HTR2C | P28335 | 2/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | KMO | O15229 | 1/20 | 0.48 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | FABP4 | P15090 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1576340 | 0.87 | KMT2A (0.60) | KMT2APPARGPPARDPPARAHTR2C | |
| SCHEMBL31177216 | 0.85 | HTR2C (0.55) | KMT2APPARGPPARDPPARAHTR2C | |
| SCHEMBL10253582 | 0.84 | KMO (0.68) | KMT2APPARGPPARDPPARAHTR2C | |
| SCHEMBL419751 | 0.81 | KMO (0.57) | PPARGPPARDPPARAHTR2CHTR2A | |
| SCHEMBL14485186 | 0.81 | KMT2A (0.57) | KMT2APPARGPPARDPPARAHTR2C | |
| SCHEMBL2869168 | 0.80 | KMT2A (0.60) | KMT2APPARGPPARDPPARAKMO | |
| SCHEMBL1576364 | 0.80 | KMO (0.72) | KMT2APPARGPPARDPPARAKMO | |
| SCHEMBL29957878 | 0.80 | KMO (0.72) | KMT2APPARGPPARDPPARAKMO | |
| SCHEMBL26683806 | 0.80 | KMT2A (0.60) | KMT2APPARGPPARDPPARAKMO | |
| SCHEMBL27898692 | 0.80 | KMT2A (0.60) | KMT2APPARGPPARDPPARAHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9688662-B2 | N-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-yl)-4-quinazolinamine and N-(2,3-dihydro-1H-indol-5-yl)-4-quinazolinamine derivatives as perk inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2017-06-27 | — | — | US | disclosed |
| US-9688662-B2 | N-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-yl)-4-quinazolinamine and N-(2,3-dihydro-1H-indol-5-yl)-4-quinazolinamine derivatives as perk inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2017-06-27 | — | — | US | disclosed |
| EP-2989091-B1 | NOVEL N-(2,3-DIHYDRO-1H-PYRROLO[2,3-B]PYRIDIN-5-YL)-4- QUINAZOLINAMINE AND N-(2,3-DIHYDRO-1H-INDOL-5-YL)-4- QUINAZOLINAMINE DERIVATIVES AS PERK INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-05-10 | — | — | EP | disclosed |
| WO-2014161808-A1 | NOVEL N-(2,3-DIHYDRO-1H-PYRROLO[2,3-B]JPYRIDIN-5-YL)-4- QUINAZOLINAMINE AND N-(2,3-DIHYDRO-1H-INDOL-5-YL)-4- QUINAZOLINAMINE DERIVATIVES AS PERK INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-10-09 | — | — | WO | disclosed |