Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.37 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16161984 | 1.00 | PPARG (0.43) | PPARGPPARASMN1; SMN2HIF1ASLC6A2 | |
| SCHEMBL476211 | 0.81 | PPARG (0.46) | PPARGPPARASMN1; SMN2HIF1ASLC6A2 | |
| SCHEMBL2641207 | 0.80 | PPARG (0.44) | PPARGPPARASMN1; SMN2HIF1ASLC6A2 | |
| SCHEMBL14675862 | 0.79 | PPARG (0.43) | PPARGPPARASMN1; SMN2HIF1ASLC6A2 | |
| SCHEMBL2365133 | 0.79 | PPARG (0.43) | PPARGPPARASMN1; SMN2HIF1ASLC6A2 | |
| SCHEMBL3656311 | 0.77 | SMN1; SMN2 (0.48) | PPARGPPARASMN1; SMN2HIF1ASLC6A2 | |
| SCHEMBL9278784 | 0.77 | HIF1A (0.48) | PPARGPPARASMN1; SMN2HIF1ASLC6A2 | |
| SCHEMBL27675004 | 0.77 | MMP8 (0.45) | PPARGPPARASMN1; SMN2HIF1ASLC6A2 | |
| SCHEMBL12993700 | 0.73 | CA12 (0.44) | PPARGPPARACYP3A4CYP1A2RECQL | |
| SCHEMBL7619909 | 0.73 | SLC6A2 (0.48) | PPARGPPARASMN1; SMN2HIF1ASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740559-B1 | 1,3,5-SUBSTITUTED PHENYL DERIVATIVE COMPOUNDS USEFUL AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME (US) | 2014-10-15 | — | — | EP | disclosed |