Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 20/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16161910 | 0.90 | BRAF (0.51) | BRAF | |
| SCHEMBL16162086 | 0.87 | BRAF (0.64) | BRAF | |
| SCHEMBL13249672 | 0.85 | BRAF (0.54) | BRAF | |
| SCHEMBL16162152 | 0.82 | BRAF (0.47) | BRAF | |
| SCHEMBL16161908 | 0.82 | BRAF (0.45) | BRAF | |
| SCHEMBL16162151 | 0.82 | CYP2D6 (0.43) | BRAF | |
| SCHEMBL16161898 | 0.81 | CYP2C9 (0.46) | BRAF | |
| SCHEMBL16162128 | 0.81 | BRAF (0.44) | BRAF | |
| SCHEMBL16162131 | 0.80 | BRAF (0.44) | BRAF | |
| SCHEMBL16161915 | 0.80 | BRAF (0.49) | BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170830-B1 | 2-FLUORO-BENZENESULFONAMIDE COMPOUNDS AS Raf KINASE MODULATORS | PLEXXIKON INC (US) | 2014-10-15 | — | — | EP | claimed |