Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1644184 | 0.76 | POLB (0.35) | POLBCYP3A4CYP2C9ALDH1A1TSHR | |
| SCHEMBL11525181 | 0.74 | POLB (0.38) | POLBCYP3A4CYP2C9 | |
| SCHEMBL4879717 | 0.70 | ALDH1A1 (0.32) | POLBALDH1A1TSHR | |
| SCHEMBL11797946 | 0.69 | HTT (0.40) | POLBCYP3A4CYP2C9 | |
| SCHEMBL1276936 | 0.66 | MEN1 (0.37) | POLBCYP3A4CYP2C9 | |
| SCHEMBL17686051 | 0.66 | TSHR (0.35) | POLBCYP3A4CYP2C9ALDH1A1TSHR | |
| SCHEMBL3317750 | 0.66 | CYP2D6 (0.41) | POLBALDH1A1 | |
| SCHEMBL407818 | 0.62 | POLB (0.33) | POLBCYP3A4CYP2C9 | |
| SCHEMBL908933 | 0.61 | TSHR (0.39) | ALDH1A1TSHR | |
| SCHEMBL410306 | 0.61 | TSHR (0.39) | ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014167528-A1 | SPIROPYRAZOLOPYRIDINE DERIVATIVES AND USES THEREOF FOR THE TREATMENT OF VIRAL INFECTIONS | NOVARTIS AG (CH) | 2014-10-16 | — | — | WO | disclosed |