SCHEMBL16166451

SCHEMBL16166451

CC(=O)Cc1cc(C=O)c2c(c1)CCN2CCCCl

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.33
MEN1 O00255 3/20 0.33
MAPT P10636 3/20 0.33
KMT2A Q03164 3/20 0.33
RECQL P46063 2/20 0.33
BLM P54132 2/20 0.33
ALPL P05186 1/20 0.33
ALPI P09923 1/20 0.33
ALPG P10696 1/20 0.33
MAPK1 P28482 1/20 0.33
APOBEC3A P31941 1/20 0.33
RXFP1 Q9HBX9 1/20 0.33
APOBEC3G Q9HC16 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
ADRA1D P25100 8/20 0.32
ADRA1A P35348 8/20 0.32
ADRA1B P35368 8/20 0.32
ALDH1A1 P00352 1/20 0.31
POLB P06746 1/20 0.31
HPGD P15428 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17502986 0.88 MEN1 (0.33) KDM4EMEN1MAPTKMT2ARECQL
SCHEMBL16166560 0.88 MEN1 (0.33) KDM4EMEN1MAPTKMT2ARECQL
SCHEMBL16166392 0.85 ADRA1D (0.32) KDM4EMEN1MAPTKMT2ARECQL
SCHEMBL16166262 0.84 ADRA1D (0.32) ADRA1DADRA1AADRA1B
SCHEMBL16166144 0.81 CYP11B2 (0.33) KDM4EMEN1MAPTKMT2ARECQL
SCHEMBL16166538 0.77 ADRA1D (0.33) KDM4EMEN1MAPTKMT2ARECQL
SCHEMBL20032558 0.73 ADRA1D (0.43) ADRA1DADRA1AADRA1B
SCHEMBL16166135 0.69 CYP11B2 (0.33) MEN1KMT2A
SCHEMBL16166555 0.68 ADRA1D (0.33) KDM4EMEN1MAPTKMT2ARECQL
SCHEMBL16166556 0.68 ADRA1D (0.33) KDM4EMEN1MAPTKMT2ARECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2984070-B1 N-HALOALKYLINDOLINE INTERMEDIATES, THEIR PROCESS AND USE IN PREPARATION OF SILODOSIN AND ITS DERIVATIVES MANKIND PHARMA LTD (IN) 2018-01-17 EP claimed
EP-2984070-A1 N-HALOALKYLINDOLINE INTERMEDIATES, THEIR PROCESS AND USE IN PREPARATION OF SILODOSIN AND ITS DERIVATIVES Mankind Research Centre (IN) 2016-02-17 EP disclosed
WO-2014167507-A1 N-HALOALKYLINDOLINE INTERMEDIATES, THEIR PROCESS AND USE IN PREPARATION OF SILODOSIN AND ITS DERIVATIVES MANKIND RESEARCH CENTRE (IN) 2014-10-16 WO disclosed