Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800765 | 0.94 | BTK (0.41) | TNK2NPC1RAB9ABTK | |
| SCHEMBL18800747 | 0.81 | KMT2A (0.46) | TNK2TP53LTA4HSMN1; SMN2KDM4E | |
| SCHEMBL18800874 | 0.80 | HTT (0.46) | TNK2SMN1; SMN2KMT2ANPC1RAB9A | |
| SCHEMBL18800471 | 0.79 | TNK2 (0.40) | TNK2LTA4HALDH1A1PTGDR2BTK | |
| SCHEMBL18800785 | 0.77 | MCL1 (0.50) | TNK2LTA4HKDM4EALDH1A1NPC1 | |
| SCHEMBL18800795 | 0.76 | BTK (0.43) | TNK2BTK | |
| SCHEMBL18800753 | 0.74 | BTK (0.49) | TNK2ADORA2ABTKADORA1 | |
| SCHEMBL18800745 | 0.74 | BTK (0.43) | TNK2LTA4HNPC1RAB9ABTK | |
| SCHEMBL18800769 | 0.73 | ADORA2A (0.48) | TNK2TP53SMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL18800492 | 0.73 | BTK (0.48) | TNK2ADORA2ABTKADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-A1 | Azaindazoles as Btk kinase modulators and use thereof | Bristol-Myers Squibb Company (US) | 2014-10-15 | — | — | EP | disclosed |