Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.48 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.47 |
| ▸ | BTK | Q06187 | 8/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | STAT1 | P42224 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | NCOA1 | Q15788 | 2/20 | 0.40 |
| ▸ | NCOA3 | Q9Y6Q9 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800747 | 0.91 | KMT2A (0.46) | ADORA2AADORA1TNK2BTKNPC1 | |
| SCHEMBL18800661 | 0.89 | ADORA1 (0.47) | ADORA1TNK2BTKFYNCHEK2 | |
| SCHEMBL18800492 | 0.89 | BTK (0.48) | ADORA2AADORA1TNK2BTK | |
| SCHEMBL18800775 | 0.88 | TNK2 (0.48) | ADORA2AADORA1TNK2BTKADORA2B | |
| SCHEMBL18800616 | 0.88 | BTK (0.47) | ADORA2AADORA1TNK2BTK | |
| SCHEMBL18800753 | 0.88 | BTK (0.49) | ADORA2AADORA1TNK2BTK | |
| SCHEMBL18800469 | 0.87 | BTK (0.61) | TNK2BTKMAPK10 | |
| SCHEMBL18800748 | 0.87 | BTK (0.42) | TNK2BTKFYNNPC1RAB9A | |
| SCHEMBL18800749 | 0.87 | TNK2 (0.49) | TNK2BTKFYNCHEK2 | |
| SCHEMBL18800463 | 0.87 | BTK (0.60) | ADORA2AADORA1TNK2BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |