Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.46 |
| ▸ | BTK | Q06187 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | STAT1 | P42224 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800753 | 0.94 | BTK (0.49) | TNK2BTKADORA2AADORA1 | |
| SCHEMBL18800492 | 0.93 | BTK (0.48) | TNK2BTKADORA2AADORA1 | |
| SCHEMBL18800616 | 0.92 | BTK (0.47) | TNK2BTKADORA2AADORA1 | |
| SCHEMBL18800769 | 0.91 | ADORA2A (0.48) | TNK2BTKALDH1A1NPC1RAB9A | |
| SCHEMBL18800564 | 0.91 | BTK (0.47) | KMT2ATNK2BTKALDH1A1NPC1 | |
| SCHEMBL18800661 | 0.89 | ADORA1 (0.47) | TNK2BTKALDH1A1L3MBTL1MAPT | |
| SCHEMBL18800651 | 0.86 | BTK (0.43) | TNK2BTK | |
| SCHEMBL16168177 | 0.86 | PARP10 (0.51) | KMT2ATNK2BTKALDH1A1 | |
| SCHEMBL18800757 | 0.86 | TNK2 (0.49) | TNK2BTK | |
| SCHEMBL18800583 | 0.85 | BTK (0.43) | TNK2BTKALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |