Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | BTK | Q06187 | 8/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800779 | 0.92 | XDH (0.47) | BTKXDHNPC1RAB9AMCL1 | |
| SCHEMBL18800677 | 0.91 | MCL1 (0.46) | BTKXDHNPC1RAB9AMCL1 | |
| SCHEMBL18800808 | 0.90 | BTK (0.42) | LTA4HBTKXDHNR1H2NR1H3 | |
| SCHEMBL18800649 | 0.89 | MEN1 (0.46) | BTKXDHNPC1RAB9AMCL1 | |
| SCHEMBL18800472 | 0.87 | XDH (0.46) | LTA4HBTKXDHNPC1RAB9A | |
| SCHEMBL18800407 | 0.87 | F2 (0.49) | BTKXDHNPC1RAB9AMCL1 | |
| SCHEMBL18800785 | 0.86 | MCL1 (0.50) | LTA4HBTKXDHNPC1RAB9A | |
| SCHEMBL18800645 | 0.86 | NPC1 (0.45) | BTKXDHNPC1RAB9AMCL1 | |
| SCHEMBL18800717 | 0.86 | BTK (0.45) | BTKXDHNPC1RAB9AMCL1 | |
| SCHEMBL18800656 | 0.85 | BTK (0.55) | BTKXDHNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-A1 | Azaindazoles as Btk kinase modulators and use thereof | Bristol-Myers Squibb Company (US) | 2014-10-15 | — | — | EP | disclosed |